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PGRMC1 progesterone receptor membrane component 1 [ Homo sapiens (human) ]

Gene ID: 10857, updated on 16-Apr-2024

Summary

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Official Symbol
PGRMC1provided by HGNC
Official Full Name
progesterone receptor membrane component 1provided by HGNC
Primary source
HGNC:HGNC:16090
See related
Ensembl:ENSG00000101856 MIM:300435; AllianceGenome:HGNC:16090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IZA; MPR; Dap1; HPR6.6
Summary
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in liver (RPKM 180.6), kidney (RPKM 113.3) and 24 other tissues See more
Orthologs
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Genomic context

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See PGRMC1 in Genome Data Viewer
Location:
Xq24
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (119236285..119244466)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (117614039..117622220)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (118370248..118378429)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 28 Neighboring gene NUDT19 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20955 Neighboring gene A-kinase anchoring protein 17B, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20956 Neighboring gene long intergenic non-protein coding RNA 3098 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:118453061-118453562

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism. Zhou J, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023 Apr 28. PMID 37385616, Free PMC Article
  2. PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis. Zhao Y, et al. Climacteric, 2023 Apr. PMID 36724820
  3. Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis. Thieffry C, et al. J Steroid Biochem Mol Biol, 2022 Oct. PMID 35835350
  4. Molecular Docking and In Silico Simulation of Trichinella spiralis Membrane-Associated Progesterone Receptor Component 2 (Ts-MAPRC2) and Its Interaction with Human PGRMC1. Aleem MT, et al. Biomed Res Int, 2022. PMID 35769668, Free PMC Article
  5. Metastasis enhancer PGRMC1 boosts store-operated Ca(2+) entry by uncoiling Ca(2+) sensor STIM1 for focal adhesion turnover and actomyosin formation. Lee SK, et al. Cell Rep, 2022 Jan 18. PMID 35045297

See all (209) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.
    Title: Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.
  2. Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.
    Title: Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.
  3. Progesterone receptor membrane component 1 facilitates Ca[2+] signal amplification between endosomes and the endoplasmic reticulum.
    Title: Progesterone receptor membrane component 1 facilitates Ca(2+) signal amplification between endosomes and the endoplasmic reticulum.
  4. Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.
    Title: Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.
  5. Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.
    Title: Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.
  6. Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma.
    Title: Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma.
  7. Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
    Title: Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
  8. PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.
    Title: PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.
  9. Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis.
    Title: Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis.
  10. PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells.
    Title: PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells.
Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amyloid-beta binding TAS
Traceable Author Statement
more info
 PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in smooth endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
membrane-associated progesterone receptor component 1
Names
progesterone binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016756.1 RefSeqGene

    Range
    5038..13219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282621.2 → NP_001269550.1  membrane-associated progesterone receptor component 1 isoform 2

    See identical proteins and their annotated locations for NP_001269550.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC004835, AK293618, HY166171, R49086
    Consensus CDS
    CCDS65313.1
    UniProtKB/Swiss-Prot
    O00264
    Related
    ENSP00000442821.1, ENST00000535419.2
    Conserved Domains (1) summary
    cl02041
    Location:74 → 107
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

  2. NM_006667.5 → NP_006658.1  membrane-associated progesterone receptor component 1 isoform 1

    See identical proteins and their annotated locations for NP_006658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004835, Y12711
    Consensus CDS
    CCDS14576.1
    UniProtKB/Swiss-Prot
    B7Z1L3, O00264, Q9UGJ9
    UniProtKB/TrEMBL
    Q6IB11
    Related
    ENSP00000217971.7, ENST00000217971.8
    Conserved Domains (1) summary
    pfam00173
    Location:74 → 137
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    119236285..119244466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    117614039..117622220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00264.3 GenPept UniProtKB/Swiss-Prot:O00264

Gene LinkOut

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