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Epsti1 epithelial stromal interaction 1 [ Mus musculus (house mouse) ]

Gene ID: 108670, updated on 2-Nov-2024

Summary

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Official Symbol
Epsti1provided by MGI
Official Full Name
epithelial stromal interaction 1provided by MGI
Primary source
MGI:MGI:1915168
See related
Ensembl:ENSMUSG00000022014 AllianceGenome:MGI:1915168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BRESI1; 2310046K10Rik; 5033415K03Rik
Summary
Acts upstream of or within several processes, including cellular response to lipopolysaccharide; cellular response to type II interferon; and macrophage differentiation. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human EPSTI1 (epithelial stromal interaction 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 10.2), thymus adult (RPKM 9.5) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Epsti1 in Genome Data Viewer
Location:
14 D3; 14 41.08 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (78141679..78240096)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77904239..78002656)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1587 Neighboring gene DnaJ heat shock protein family (Hsp40) member C15 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:78261113-78261296 Neighboring gene STARR-seq mESC enhancer starr_37217 Neighboring gene STARR-seq mESC enhancer starr_37218 Neighboring gene family with sequence similarity 216, member B Neighboring gene predicted gene, 30608

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of inflammatory gene expression in macrophages by epithelial-stromal interaction 1 (Epsti1). Kim YH, et al. Biochem Biophys Res Commun, 2018 Feb 5. PMID 29217193
  2. EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression. Bei YR, et al. Acta Pharmacol Sin, 2023 Jan. PMID 35778487, Free PMC Article
  3. Integrating genetic and network analysis to characterize genes related to mouse weight. Ghazalpour A, et al. PLoS Genet, 2006 Aug 18. PMID 16934000, Free PMC Article
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within macrophage activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
epithelial-stromal interaction protein 1
Names
epithelial stromal interaction 1 (breast)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029495.2 → NP_083771.1  epithelial-stromal interaction protein 1 isoform a

    See identical proteins and their annotated locations for NP_083771.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK077223, AK135710, BY719992
    Consensus CDS
    CCDS56971.1
    UniProtKB/Swiss-Prot
    Q80WK5, Q8VDI1, Q8VDW6
    UniProtKB/TrEMBL
    A0A140T8I6
    Related
    ENSMUSP00000022591.9, ENSMUST00000022591.16
    Conserved Domains (1) summary
    pfam04687
    Location:13 → 197
    Microvir_H; Microvirus H protein (pilot protein)

  2. NM_178825.4 → NP_849147.1  epithelial-stromal interaction protein 1 isoform b

    See identical proteins and their annotated locations for NP_849147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) uses an alternate 3' coding region and 3' UTR, compared to variant a. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI592213, AK017174, BE628578, BY719992
    Consensus CDS
    CCDS88718.1
    UniProtKB/TrEMBL
    Q9D3Q7
    Related
    ENSMUSP00000154502.2, ENSMUST00000227903.2
    Conserved Domains (1) summary
    pfam04687
    Location:13 → 197
    Microvir_H; Microvirus H protein (pilot protein)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    78141679..78240096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDI1.2 GenPept UniProtKB/Swiss-Prot:Q8VDI1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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