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CD300C CD300c molecule [ Homo sapiens (human) ]

Gene ID: 10871, updated on 11-Apr-2024

Summary

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Official Symbol
CD300Cprovided by HGNC
Official Full Name
CD300c moleculeprovided by HGNC
Primary source
HGNC:HGNC:19320
See related
Ensembl:ENSG00000167850 MIM:606786; AllianceGenome:HGNC:19320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIR; CLM-6; CMRF35; IGSF16; CMRF-35; CMRF35A; CMRF-35A; CMRF35A1; CMRF35-A1
Summary
The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in lung (RPKM 2.9), appendix (RPKM 2.6) and 19 other tissues See more
Orthologs
mouse all
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Genomic context

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See CD300C in Genome Data Viewer
Location:
17q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74534635..74546115, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75425156..75436636, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72537212..72542254, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12707 Neighboring gene CD300a molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12710 Neighboring gene uncharacterized LOC107985074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12712 Neighboring gene CD300 molecule like family member b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72535116-72535616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72546952-72547452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72547453-72547953 Neighboring gene CD300H molecule (gene/pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72564995-72565725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72565726-72566455 Neighboring gene CD300LD antisense RNA 1 Neighboring gene CD300 molecule like family member d Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12713

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A CD300c-Fc Fusion Protein Inhibits T Cell Immunity. Cui C, et al. Front Immunol, 2018. PMID 30498497, Free PMC Article
  2. CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy. Zenarruzabeitia O, et al. J Allergy Clin Immunol, 2019 Feb. PMID 29906528
  3. CD300c is an activating receptor expressed on human monocytes. Simhadri VR, et al. J Innate Immun, 2013. PMID 23571507, Free PMC Article
  4. The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. Clark GJ, et al. Tissue Antigens, 2001 May. PMID 11556966
  5. CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition. Dimitrova M, et al. Sci Rep, 2016 Apr 4. PMID 27040328, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD300c could be considered a biomarker and therapeutic target in patients with IgE-mediated allergic diseases
    Title: CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy.
  2. Administration of CD300c-Fc protein attenuates graft-vs.-host disease (GVHD) in mice.
    Title: A CD300c-Fc Fusion Protein Inhibits T Cell Immunity.
  3. Results show that CD300c is exclusively expressed on CD56bright natural killer cells and differentially binds to phosphatidylethanolamine and phosphatidylserine. This expression is under the regulation of STAT5 and Il-4.
    Title: CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.
  4. potential role in inflammatory responses
    Title: CD300c is an activating receptor expressed on human monocytes.
  5. engagement of CD300C led to Fc receptor gamma-dependent activation of mast cells and monocytes
    Title: Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.
  6. differential expression on human TH1 and TH17 cell memory subsets
    Title: Differential expression of CD300a/c on human TH1 and TH17 cells.
  7. CD300a and CD300c receptors are indistinguishable on the surface of natural killer (NK) cells. The tyrosine residue in the third ITIM motif, Tyr-267-Ala, is the most important residue for execution of the inhibitory signal.
    Title: Expression and function of CD300 in NK cells.
  8. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs; CD300a/c RNA and surface expression were downregulated after stimulation of pDCs with TLR7 and TLR9 ligands
    Title: CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands.
  9. CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35A induces cellular activation and effector function [review]
    Title: CMRF-35A, CMRF-35H: potential new CD.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
CMRF35-like molecule 6
Names
CD300 antigen-like family member C
CD300c antigen
CMRF35 antigen
CMRF35 leukocyte immunoglobulin-like receptor
CMRF35A leukocyte immunoglobulin-like receptor
immunoglobulin superfamily member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006678.5 → NP_006669.1  CMRF35-like molecule 6 precursor

    See identical proteins and their annotated locations for NP_006669.1

    Status: VALIDATED

    Source sequence(s)
    AC079325, BC022279, BF508242
    Consensus CDS
    CCDS11701.1
    UniProtKB/Swiss-Prot
    Q08708
    Related
    ENSP00000329507.1, ENST00000330793.2
    Conserved Domains (2) summary
    cd05716
    Location:30 → 119
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    cl11960
    Location:95 → 183
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74534635..74546115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024033.3 → XP_016879522.1  CMRF35-like molecule 6 isoform X1

  2. XM_047435157.1 → XP_047291113.1  CMRF35-like molecule 6 isoform X2

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791806.1 Reference GRCh38.p14 PATCHES

    Range
    111083..122563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333226.1 → XP_054189201.1  CMRF35-like molecule 6 isoform X1

  2. XM_054333227.1 → XP_054189202.1  CMRF35-like molecule 6 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75425156..75436636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314749.1 → XP_054170724.1  CMRF35-like molecule 6 isoform X1

  2. XM_054314750.1 → XP_054170725.1  CMRF35-like molecule 6 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08708.1 GenPept UniProtKB/Swiss-Prot:Q08708

Gene LinkOut

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