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CEACAM8 CEA cell adhesion molecule 8 [ Homo sapiens (human) ]

Gene ID: 1088, updated on 2-Nov-2024

Summary

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Official Symbol
CEACAM8provided by HGNC
Official Full Name
CEA cell adhesion molecule 8provided by HGNC
Primary source
HGNC:HGNC:1820
See related
Ensembl:ENSG00000124469 MIM:615747; AllianceGenome:HGNC:1820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD67; CGM6; CD66b; NCA-95
Summary
Enables protein heterodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell surface and extracellular space. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward bone marrow (RPKM 58.6) See more
Orthologs
all
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Genomic context

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See CEACAM8 in Genome Data Viewer
Location:
19q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42580243..42594924, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45399652..45414338, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43084395..43099076, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIPE antisense RNA 1 Neighboring gene uncharacterized LOC105372407 Neighboring gene CEA cell adhesion molecule 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:43032933-43033795 Neighboring gene MPRA-validated peak3492 silencer Neighboring gene MPRA-validated peak3493 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43064131-43064631 Neighboring gene CEA cell adhesion molecule pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43100409-43100909 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:43132188-43133387 Neighboring gene CEA cell adhesion molecule pseudogene 1 Neighboring gene CEA cell adhesion molecule pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical Significance of CD66b Expression in Non-Small Cell Lung Cancer. Kovaleva OV, et al. Bull Exp Biol Med, 2023 Apr. PMID 37162631
  2. Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes. Zhao L, et al. J Immunol Methods, 2002 Dec 1. PMID 12379336
  3. CD66b regulates adhesion and activation of human eosinophils. Yoon J, et al. J Immunol, 2007 Dec 15. PMID 18056392
  4. Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. Torsteinsdóttir I, et al. Scand J Immunol, 1999 Oct. PMID 10520185
  5. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. Eades-Perner AM, et al. Blood, 1998 Jan 15. PMID 9427723

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical Significance of CD66b Expression in Non-Small Cell Lung Cancer.
    Title: Clinical Significance of CD66b Expression in Non-Small Cell Lung Cancer.
  2. CD66b(+) monocytes represent a proinflammatory myeloid subpopulation in cancer.
    Title: CD66b(+) monocytes represent a proinflammatory myeloid subpopulation in cancer.
  3. High CEACAM8 expression is associated with metastases in breast carcinoma.
    Title: Co-expression of carcinoembryonic antigen-related cell adhesion molecule 6 and 8 inhibits proliferation and invasiveness of breast carcinoma cells.
  4. Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis.
    Title: Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor.
  5. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8
    Title: A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.
  6. Inhibition of C5aR1 leads to a significant reduction of CD66b and CD11b expression indicating a lower neutrophil activation status and block of granule exocytosis.
    Title: CD66b Overexpression and Loss of C5a Receptors as Surface Markers for Staphylococcus aureus-Induced Neutrophil Dysfunction.
  7. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another.
    Title: Diverse oligomeric states of CEACAM IgV domains.
  8. CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses
    Title: Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.
  9. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls.
    Title: Fasting glucose level modulates cell surface expression of CD11b and CD66b in granulocytes and monocytes of patients with type 2 diabetes.
  10. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation.
    Title: High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 8
Names
CD67 antigen
carcinoembryonic antigen CGM6
carcinoembryonic antigen gene family member 6
carcinoembryonic antigen related cell adhesion molecule 8
non-specific cross-reacting antigen NCA-95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001816.4 → NP_001807.2  carcinoembryonic antigen-related cell adhesion molecule 8 precursor

    See identical proteins and their annotated locations for NP_001807.2

    Status: VALIDATED

    Source sequence(s)
    AK297012, BC026263, DA464901
    Consensus CDS
    CCDS12610.1
    UniProtKB/Swiss-Prot
    O60399, P31997, Q16574
    UniProtKB/TrEMBL
    Q0Z7S6
    Related
    ENSP00000244336.5, ENST00000244336.10
    Conserved Domains (3) summary
    pfam13895
    Location:239 → 307
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:146 → 234
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42580243..42594924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026195.2 → XP_016881684.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X3

    UniProtKB/Swiss-Prot
    O60399, P31997, Q16574
    UniProtKB/TrEMBL
    Q0Z7S6
    Conserved Domains (3) summary
    pfam13895
    Location:239 → 307
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:146 → 234
    Ig; Immunoglobulin domain

  2. XM_011526341.2 → XP_011524643.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X5

    See identical proteins and their annotated locations for XP_011524643.1

    Conserved Domains (3) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157 → 233
    IG_like; Immunoglobulin like
    cl11960
    Location:146 → 234
    Ig; Immunoglobulin domain

  3. XM_047438091.1 → XP_047294047.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X2

  4. XM_017026197.3 → XP_016881686.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X4

  5. XM_011526340.3 → XP_011524642.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X1

    Conserved Domains (4) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244 → 312
    IG_like; Immunoglobulin like
    pfam13895
    Location:240 → 318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:146 → 234
    Ig; Immunoglobulin domain

  6. XM_011526342.2 → XP_011524644.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X5

    See identical proteins and their annotated locations for XP_011524644.1

    Conserved Domains (3) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157 → 233
    IG_like; Immunoglobulin like
    cl11960
    Location:146 → 234
    Ig; Immunoglobulin domain

RNA

  1. XR_007066548.1 RNA Sequence

  2. XR_007066546.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45399652..45414338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319599.1 → XP_054175574.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X5

  2. XM_054319597.1 → XP_054175572.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X2

  3. XM_054319596.1 → XP_054175571.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X1

  4. XM_054319598.1 → XP_054175573.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X4

  5. XM_054319600.1 → XP_054175575.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X5

RNA

  1. XR_008485070.1 RNA Sequence

  2. XR_008485069.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31997.2 GenPept UniProtKB/Swiss-Prot:P31997

Gene LinkOut

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