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Ccdc122 coiled-coil domain containing 122 [ Mus musculus (house mouse) ]

Gene ID: 108811, updated on 2-Nov-2024

Summary

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Official Symbol
Ccdc122provided by MGI
Official Full Name
coiled-coil domain containing 122provided by MGI
Primary source
MGI:MGI:1918358
See related
Ensembl:ENSMUSG00000034795 AllianceGenome:MGI:1918358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933415L06Rik
Summary
Orthologous to human CCDC122 (coiled-coil domain containing 122). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 4.3), bladder adult (RPKM 2.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc122 in Genome Data Viewer
Location:
14 D3; 14 40.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (77274212..77349703)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77036772..77112263)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37199 Neighboring gene STARR-seq mESC enhancer starr_37200 Neighboring gene predicted gene, 30365 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77411648-77411949 Neighboring gene STARR-seq mESC enhancer starr_37202 Neighboring gene STARR-seq mESC enhancer starr_37203 Neighboring gene STARR-positive B cell enhancer ABC_E5459 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_37204 Neighboring gene laccase domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77541449-77541750 Neighboring gene STARR-seq mESC enhancer starr_37206 Neighboring gene ecto-NOX disulfide-thiol exchanger 1 Neighboring gene STARR-seq mESC enhancer starr_37207 Neighboring gene STARR-seq mESC enhancer starr_37208 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene predicted gene, 41217

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC106895

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 122

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310648.1 → NP_001297577.1  coiled-coil domain-containing protein 122 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK077161, AW554226, BC145455
    UniProtKB/Swiss-Prot
    Q8BVN0
    Conserved Domains (1) summary
    pfam13166
    Location:18 → 208
    AAA_13; AAA domain

  2. NM_001310649.1 → NP_001297578.1  coiled-coil domain-containing protein 122 isoform 3

    See identical proteins and their annotated locations for NP_001297578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the 5' and central coding regions, compared to variant 1. The encoded isoform (3) is shorter, but has the same N- and C-termini, as isoform 1.
    Source sequence(s)
    AK077161, AW554226, BC096577
    Consensus CDS
    CCDS79346.1
    UniProtKB/TrEMBL
    Q4VA24
    Related
    ENSMUSP00000093285.5, ENSMUST00000095625.11
    Conserved Domains (1) summary
    pfam07851
    Location:28 → 104
    TMPIT; TMPIT-like protein

  3. NM_175369.4 → NP_780578.1  coiled-coil domain-containing protein 122 isoform 1

    See identical proteins and their annotated locations for NP_780578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK077161, AW554226
    Consensus CDS
    CCDS27288.1
    UniProtKB/Swiss-Prot
    B2RSJ0, Q8BVN0
    Related
    ENSMUSP00000036369.4, ENSMUST00000048208.10
    Conserved Domains (1) summary
    TIGR02169
    Location:15 → 288
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    77274212..77349703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVN0.1 GenPept UniProtKB/Swiss-Prot:Q8BVN0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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