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Miga2 mitoguardin 2 [ Mus musculus (house mouse) ]

Gene ID: 108958, updated on 2-Nov-2024

Summary

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Official Symbol
Miga2provided by MGI
Official Full Name
mitoguardin 2provided by MGI
Primary source
MGI:MGI:1922035
See related
Ensembl:ENSMUSG00000026858 AllianceGenome:MGI:1922035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam73b; C9orf54; 5730472N09Rik
Summary
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Acts upstream of or within bone development. Predicted to be located in plasma membrane. Orthologous to human MIGA2 (mitoguardin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 26.5), mammary gland adult (RPKM 21.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Miga2 in Genome Data Viewer
Location:
2 B; 2 21.63 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30254232..30275532)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30364233..30385520)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nucleoporin 188 Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene STARR-positive B cell enhancer ABC_E410 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase Neighboring gene protein phosphatase 2 protein activator Neighboring gene STARR-positive B cell enhancer ABC_E5903 Neighboring gene STARR-seq mESC enhancer starr_04096

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway. Yan MQ, et al. Cell Death Dis, 2023 Nov 27. PMID 38012141, Free PMC Article
  2. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. Liu XM, et al. Oncotarget, 2016 Jan 12. PMID 26716412, Free PMC Article
  3. Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability. Gao Z, et al. Nat Commun, 2017 Nov 27. PMID 29180626, Free PMC Article
  4. Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation. Liu XM, et al. Endocrinology, 2017 Nov 1. PMID 28938432
  5. MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis. Podrini C, et al. FASEB J, 2015 May. PMID 25526730

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ovarian phenotypes of these mice suggested that the MIGA1/2 proteins play an important role in ovulation and ovarian steroidogenesis. In vivo and in vitro analyses of Miga1/2-knockout granulosa cells showed severe defects in luteinization and steroidogenesis and disordered mitochondrial morphology and function in response to gonadotropins.
    Title: Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation.
  2. Data indicate that mitoguardin (Miga) knoskout Miga1/2-/- females show greatly reduced quality of oocytes and early embryos and are subfertile.
    Title: Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.
  3. Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.
    Title: Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitoguardin 2
Names
family with sequence similarity 73, member B
mFLJ00199 protein
ortholog of family with sequence similarity 73, member B FAM73B
protein FAM73B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242407.2 → NP_001229336.1  mitoguardin 2 isoform 1

    See identical proteins and their annotated locations for NP_001229336.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL954388
    Consensus CDS
    CCDS15880.1
    UniProtKB/Swiss-Prot
    A6PX05, Q3U4J7, Q3UST7, Q8BK03
    Related
    ENSMUSP00000077127.8, ENSMUST00000077977.14
    Conserved Domains (1) summary
    pfam10265
    Location:31 → 568
    DUF2217; Uncharacterized conserved protein (DUF2217)

  2. NM_001378906.1 → NP_001365835.1  mitoguardin 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Conserved Domains (1) summary
    pfam10265
    Location:31 → 529
    Miga; Mitoguardin

  3. NM_001378907.1 → NP_001365836.1  mitoguardin 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Conserved Domains (1) summary
    pfam10265
    Location:31 → 529
    Miga; Mitoguardin

  4. NM_001378909.1 → NP_001365838.1  mitoguardin 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Conserved Domains (1) summary
    pfam10265
    Location:30 → 377
    Miga; Mitoguardin

  5. NM_001378911.1 → NP_001365840.1  mitoguardin 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Conserved Domains (1) summary
    pfam10265
    Location:30 → 377
    Miga; Mitoguardin

  6. NM_001407284.1 → NP_001394213.1  mitoguardin 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL954388

  7. NM_175392.3 → NP_780601.1  mitoguardin 2 isoform 1

    See identical proteins and their annotated locations for NP_780601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC051404
    Consensus CDS
    CCDS15880.1
    UniProtKB/Swiss-Prot
    A6PX05, Q3U4J7, Q3UST7, Q8BK03
    Related
    ENSMUSP00000097787.4, ENSMUST00000100214.10
    Conserved Domains (1) summary
    pfam10265
    Location:31 → 568
    DUF2217; Uncharacterized conserved protein (DUF2217)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30254232..30275532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497594.2 → XP_006497657.1  mitoguardin 2 isoform X2

    Conserved Domains (1) summary
    pfam10265
    Location:117 → 615
    Miga; Mitoguardin

  2. XM_030246575.1 → XP_030102435.1  mitoguardin 2 isoform X3

    Conserved Domains (1) summary
    pfam10265
    Location:30 → 377
    Miga; Mitoguardin

RNA

  1. XR_003949993.2 RNA Sequence

  2. XR_003949994.2 RNA Sequence

  3. XR_866005.2 RNA Sequence

  4. XR_003949995.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BK03.1 GenPept UniProtKB/Swiss-Prot:Q8BK03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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