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Trip11 thyroid hormone receptor interactor 11 [ Mus musculus (house mouse) ]

Gene ID: 109181, updated on 2-Nov-2024

Summary

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Official Symbol
Trip11provided by MGI
Official Full Name
thyroid hormone receptor interactor 11provided by MGI
Primary source
MGI:MGI:1924393
See related
Ensembl:ENSMUSG00000021188 AllianceGenome:MGI:1924393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRIP230; GMAP-210; 2610511G22Rik; 3110031G15Rik; 6030460N08Rik
Summary
Predicted to enable small GTPase binding activity. Acts upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; inner ear receptor cell stereocilium organization; and ventricular septum development. Located in acrosomal membrane and cis-Golgi network. Is expressed in cranium. Used to study achondrogenesis type IA. Human ortholog(s) of this gene implicated in achondrogenesis type IA. Orthologous to human TRIP11 (thyroid hormone receptor interactor 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 5.0), cerebellum adult (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trip11 in Genome Data Viewer
Location:
12 E; 12 51.3 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (101800304..101879463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (101834045..101913171, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52022 Neighboring gene tandem C2 domains, nuclear Neighboring gene fibulin 5 Neighboring gene STARR-seq mESC enhancer starr_33088 Neighboring gene STARR-seq mESC enhancer starr_33091 Neighboring gene predicted gene, 20036 Neighboring gene ataxin 3 Neighboring gene STARR-positive B cell enhancer ABC_E1452 Neighboring gene STARR-seq mESC enhancer starr_33093 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene cleavage and polyadenylation specific factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice. Wang Z, et al. Am J Physiol Cell Physiol, 2020 Jan 1. PMID 31577511, Free PMC Article
  2. The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects. Bird IM, et al. Development, 2018 Jan 8. PMID 29180569, Free PMC Article
  3. Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. Beischlag TV, et al. J Biol Chem, 2004 Dec 24. PMID 15485806
  4. GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail. Kierszenbaum AL, et al. Dev Dyn, 2011 Mar. PMID 21337470, Free PMC Article
  5. Golgi disruption and early embryonic lethality in mice lacking USO1. Kim S, et al. PLoS One, 2012. PMID 23185636, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice.
    Title: Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice.
  2. GMAP210 is essential for acrosome biogenesis, normal mitochondrial sheath formation, and male fertility, and it determines expression levels and acrosomal localization of IFT20 and other acrosomal proteins.
    Title: Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice.
  3. Data show that IFT88 is present in the Golgi of spermatids, that the microtubule-associated golgin GMAP210 and IFT88 participate in acrosome, HTCA, and tail biogenesis.
    Title: GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail.
  4. mice with lethal skeletal dysplasia had a nonsense mutation in the thyroid hormone receptor interactor 11 gene (Trip11), which encodes the Golgi microtubule-associated protein 210 (GMAP-210)
    Title: Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.
  5. GMAP210 and IFT20 function together at the Golgi in the sorting of proteins destined for the ciliary membrane.
    Title: The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC189992

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cartilage development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inner ear receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle tethering to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in inner acrosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in outer acrosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thyroid receptor-interacting protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028446.1 → NP_082722.1  thyroid receptor-interacting protein 11

    Status: VALIDATED

    Source sequence(s)
    AC121965
    Consensus CDS
    CCDS49143.1
    UniProtKB/TrEMBL
    B2RY51, E9Q512
    Related
    ENSMUSP00000021605.8, ENSMUST00000021605.14
    Conserved Domains (2) summary
    COG1196
    Location:946 → 1768
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:226 → 1065
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    101800304..101879463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515382.4 → XP_006515445.1  thyroid receptor-interacting protein 11 isoform X1

    UniProtKB/TrEMBL
    B2RY51
    Conserved Domains (2) summary
    COG1196
    Location:945 → 1767
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:225 → 1064
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_011243986.3 → XP_011242288.1  thyroid receptor-interacting protein 11 isoform X2

    UniProtKB/TrEMBL
    B2RY51
    Conserved Domains (2) summary
    COG1196
    Location:882 → 1704
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:162 → 1001
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_036157159.1 → XP_036013052.1  thyroid receptor-interacting protein 11 isoform X3

    UniProtKB/TrEMBL
    H3BJG4
    Conserved Domains (2) summary
    COG1196
    Location:10 → 764
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10375
    Location:1370 → 1415
    GRAB; GRIP-related Arf-binding domain

RNA

  1. XR_004937402.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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