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Actr5 ARP5 actin-related protein 5 [ Mus musculus (house mouse) ]

Gene ID: 109275, updated on 2-Nov-2024

Summary

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Official Symbol
Actr5provided by MGI
Official Full Name
ARP5 actin-related protein 5provided by MGI
Primary source
MGI:MGI:1924748
See related
Ensembl:ENSMUSG00000037761 AllianceGenome:MGI:1924748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B430109J19Rik
Summary
Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in nucleus. Predicted to be part of Ino80 complex. Predicted to be active in cytoplasm. Is expressed in bone; brain; cartilage; and genitourinary system. Orthologous to human ACTR5 (actin related protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 7.1), CNS E11.5 (RPKM 4.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Actr5 in Genome Data Viewer
Location:
2 H1; 2 78.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158466800..158481131)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158624881..158639211)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 40 Neighboring gene predicted gene 14204 Neighboring gene STARR-positive B cell enhancer ABC_E4515 Neighboring gene solute carrier family 32 (GABA vesicular transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E10158 Neighboring gene microRNA 3474 Neighboring gene STARR-positive B cell enhancer ABC_E7879 Neighboring gene STARR-positive B cell enhancer mm9_chr2:158499319-158499620 Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene STARR-positive B cell enhancer ABC_E2650 Neighboring gene STARR-positive B cell enhancer ABC_E7880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:158548828-158549026 Neighboring gene STARR-positive B cell enhancer ABC_E2056 Neighboring gene STARR-positive B cell enhancer ABC_E7881 Neighboring gene STARR-positive B cell enhancer ABC_E416 Neighboring gene family with sequence similarity 83, member D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma. Morita T, et al. Elife, 2022 Mar 29. PMID 35348112, Free PMC Article
  2. Actin-related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2. Morita T, et al. FEBS Open Bio, 2023 Feb. PMID 36610028, Free PMC Article
  3. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Min JN, et al. Cell Res, 2013 Dec. PMID 23979016, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Actin-related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2.
    Title: Actin-related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2.
  2. Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma.
    Title: Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in UV-damage excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
actin-related protein 5
Names
ARP5 actin-related protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175419.4 → NP_780628.3  actin-related protein 5

    Status: VALIDATED

    Source sequence(s)
    AK142980, CR516445
    Consensus CDS
    CCDS38310.1
    UniProtKB/Swiss-Prot
    A2ACC9, Q80US4, Q8BL26
    UniProtKB/TrEMBL
    A0A0A0MQ89
    Related
    ENSMUSP00000046658.9, ENSMUST00000045644.9
    Conserved Domains (2) summary
    smart00268
    Location:32 → 562
    ACTIN; Actin
    cl17037
    Location:27 → 570
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    158466800..158481131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498566.3 → XP_006498629.1  actin-related protein 5 isoform X1

    Related
    ENSMUST00000142531.8
    Conserved Domains (1) summary
    cl17037
    Location:2 → 416
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_017314917.3 → XP_017170406.1  actin-related protein 5 isoform X2

    Conserved Domains (1) summary
    cl17037
    Location:144 → 302
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RNA

  1. XR_003950024.2 RNA Sequence

    Related
    ENSMUST00000183731.8

  2. XR_003950026.2 RNA Sequence

  3. XR_004937529.1 RNA Sequence

  4. XR_001780405.3 RNA Sequence

  5. XR_001780406.3 RNA Sequence

  6. XR_866206.3 RNA Sequence

  7. XR_374386.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80US4.3 GenPept UniProtKB/Swiss-Prot:Q80US4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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