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Rnf20 ring finger protein 20 [ Mus musculus (house mouse) ]

Gene ID: 109331, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf20provided by MGI
Official Full Name
ring finger protein 20provided by MGI
Primary source
MGI:MGI:1925927
See related
Ensembl:ENSMUSG00000028309 AllianceGenome:MGI:1925927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4116; 4833430L21Rik
Summary
Enables chromatin binding activity and histone H2B C-terminal K residue ubiquitin ligase activity. Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RNF20 (ring finger protein 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 22.3), CNS E14 (RPKM 15.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf20 in Genome Data Viewer
Location:
4 B1; 4 26.69 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49632005..49656887)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49632005..49656887)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10187 Neighboring gene STARR-positive B cell enhancer ABC_E2112 Neighboring gene predicted gene, 33159 Neighboring gene predicted gene, 45952 Neighboring gene glutamate receptor ionotropic, NMDA3A Neighboring gene protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) Neighboring gene STARR-seq mESC enhancer starr_10189 Neighboring gene STARR-seq mESC enhancer starr_10190 Neighboring gene predicted gene, 25485

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. R-loops and genomic instability in Bre1 (RNF20/40)-deficient cells. Chernikova SB, et al. Cell Cycle, 2012 Aug 15. PMID 22825248, Free PMC Article
  2. Impact of Ring Finger Protein 20 and Its Downstream Regulation on Renal Tubular Injury in a Unilateral Nephrectomy Mouse Model Fed a High-Fat Diet. Kim YJ, et al. Nutrients, 2023 Nov 29. PMID 38068817, Free PMC Article
  3. Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization. Lin CY, et al. Cell Rep, 2023 Nov 28. PMID 37967007
  4. Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0. Zhao Y, et al. Cell Mol Life Sci, 2023 Aug 9. PMID 37555936, Free PMC Article
  5. RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells. Lai F, et al. Cell Biosci, 2023 Apr 6. PMID 37024990, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF20-mediated transcriptional pausing and VEGFA splicing orchestrate vessel growth.
    Title: RNF20-mediated transcriptional pausing and VEGFA splicing orchestrate vessel growth.
  2. Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates.
    Title: Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates.
  3. Impact of Ring Finger Protein 20 and Its Downstream Regulation on Renal Tubular Injury in a Unilateral Nephrectomy Mouse Model Fed a High-Fat Diet.
    Title: Impact of Ring Finger Protein 20 and Its Downstream Regulation on Renal Tubular Injury in a Unilateral Nephrectomy Mouse Model Fed a High-Fat Diet.
  4. Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization.
    Title: Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization.
  5. Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0.
    Title: Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0.
  6. RNF20 deletion causes inflammation in model of sepsis through the NLRP3 activation.
    Title: RNF20 deletion causes inflammation in model of sepsis through the NLRP3 activation.
  7. RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo.
    Title: RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo.
  8. Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development.
    Title: Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development.
  9. Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis.
    Title: Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis.
  10. Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation.
    Title: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4116

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2B C-terminal K residue ubiquitin ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H2B C-terminal K residue ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HULC complex ISO
Inferred from Sequence Orthology
more info
  
part_of HULC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase BRE1A
Names
BRE1-A
RING-type E3 ubiquitin transferase BRE1A
NP_001156735.1
NP_001343330.1
NP_892044.1
XP_006537616.1
XP_011248208.1
XP_030108941.1
XP_036019473.1
XP_036019474.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163263.1 → NP_001156735.1  E3 ubiquitin-protein ligase BRE1A isoform 1

    See identical proteins and their annotated locations for NP_001156735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK051278, AK139883, BF730643, BQ442966, CJ052397, CN531555, DV660388
    Consensus CDS
    CCDS18178.1
    UniProtKB/Swiss-Prot
    A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
    Related
    ENSMUSP00000128546.2, ENSMUST00000167496.8
    Conserved Domains (3) summary
    PTZ00121
    Location:320 → 934
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:41 → 394
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16704
    Location:918 → 963
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  2. NM_001356401.1 → NP_001343330.1  E3 ubiquitin-protein ligase BRE1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK053783, AK139883, AL732521, BF730643, BQ442966, CN531555, DV660388
    Conserved Domains (2) summary
    PTZ00121
    Location:75 → 689
    PTZ00121; MAEBL; Provisional
    cd16704
    Location:673 → 718
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  3. NM_182999.2 → NP_892044.1  E3 ubiquitin-protein ligase BRE1A isoform 1

    See identical proteins and their annotated locations for NP_892044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK053783, AK139883, BF730643, BQ442966, CJ052397, CN531555, DV660388
    Consensus CDS
    CCDS18178.1
    UniProtKB/Swiss-Prot
    A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
    Related
    ENSMUSP00000029989.5, ENSMUST00000029989.11
    Conserved Domains (3) summary
    PTZ00121
    Location:320 → 934
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:41 → 394
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16704
    Location:918 → 963
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    49632005..49656887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537553.4 → XP_006537616.1  E3 ubiquitin-protein ligase BRE1A isoform X1

    See identical proteins and their annotated locations for XP_006537616.1

    UniProtKB/Swiss-Prot
    A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
    Conserved Domains (3) summary
    PTZ00121
    Location:320 → 934
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:41 → 394
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16704
    Location:918 → 963
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  2. XM_011249906.4 → XP_011248208.1  E3 ubiquitin-protein ligase BRE1A isoform X1

    See identical proteins and their annotated locations for XP_011248208.1

    UniProtKB/Swiss-Prot
    A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
    Conserved Domains (3) summary
    PTZ00121
    Location:320 → 934
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:41 → 394
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16704
    Location:918 → 963
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  3. XM_036163580.1 → XP_036019473.1  E3 ubiquitin-protein ligase BRE1A isoform X2

    Conserved Domains (2) summary
    PTZ00121
    Location:75 → 689
    PTZ00121; MAEBL; Provisional
    cd16704
    Location:673 → 718
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  4. XM_036163581.1 → XP_036019474.1  E3 ubiquitin-protein ligase BRE1A isoform X3

    Conserved Domains (2) summary
    PTZ00121
    Location:51 → 665
    PTZ00121; MAEBL; Provisional
    cd16704
    Location:649 → 694
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  5. XM_030253081.2 → XP_030108941.1  E3 ubiquitin-protein ligase BRE1A isoform X2

    Conserved Domains (2) summary
    PTZ00121
    Location:75 → 689
    PTZ00121; MAEBL; Provisional
    cd16704
    Location:673 → 718
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DTM8.2 GenPept UniProtKB/Swiss-Prot:Q5DTM8

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