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LOC109461473 BMP7 promoter region [ Homo sapiens (human) ]

Gene ID: 109461473, updated on 10-Oct-2023

Summary

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Gene symbol
LOC109461473
Gene description
BMP7 promoter region
Gene type
biological region
Feature type(s)
regulatory: promoter, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents the promoter of the bone morphogenetic protein 7 gene. This sequence may be induced by retinoic acid and prostaglandin, and regulated by association of paired box, LIM domain, and GLI family zinc finger proteins. [provided by RefSeq, Dec 2016]
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Genomic context

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Location:
chromosome: 20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (57266129..57269490)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (59043870..59047231)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (55841185..55844546)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2565 Neighboring gene uncharacterized LOC105372686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55736368-55736868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55747859-55748360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55758285-55758807 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55758808-55759329 Neighboring gene bone morphogenetic protein 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:55773380-55774038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:55774039-55774698 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:55780300-55781499 Neighboring gene BMP7 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55798567-55799068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55801141-55801641 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:55806824-55807357 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:55807358-55807890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55819232-55820156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55834429-55834991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55837926-55838642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55839361-55840076 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC105372687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55861989-55862490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55862491-55862990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55865617-55866584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55867403-55867902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55876343-55876878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55892097-55892598 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:55901391-55901894 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:55901895-55902397 Neighboring gene microRNA 4325 Neighboring gene ribosomal protein L39 pseudogene 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of the bone morphogenetic protein 7 gene in developmental and adult life. Oxburgh L. Curr Genomics, 2009 Jun. PMID 19949543, Free PMC Article
  2. The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells. Wang N, et al. Oncogene, 2007 Sep 27. PMID 17452977
  3. Regulation of BMP-7 expression by retinoic acid and prostaglandin E(2). Paralkar VM, et al. J Cell Physiol, 2002 Feb. PMID 11807825
  4. The 5' flanking region of the human bone morphogenetic protein-7 gene. Dorai H, et al. Biochem Biophys Res Commun, 2001 Apr 6. PMID 11401538
  5. OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. Ozkaynak E, et al. EMBO J, 1990 Jul. PMID 2357959, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052608.1 

    Range
    101..3462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    57266129..57269490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    59043870..59047231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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