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ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough [ Homo sapiens (human) ]

Gene ID: 109504726, updated on 17-Sep-2024

Summary

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Gene symbol
ERV3-1-ZNF117
Gene description
ERV3-1-ZNF117 readthrough
See related
Ensembl:ENSG00000152926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
h-PLK
Summary
This locus represents naturally occurring readthrough transcription between the endogenous retrovirus group 3 member 1 (ERV3-1) and the zinc finger protein 117 (ZNF117) genes on chromosome 7. Readthrough transcripts may encode the same protein as the ZNF117 gene. [provided by RefSeq, Jan 2017]
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Genomic context

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See ERV3-1-ZNF117 in Genome Data Viewer
Location:
7q11.21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64971776..65006746, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (66177979..66212924, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64432154..64467124, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 273 Neighboring gene vomeronasal 1 receptor 42 pseudogene Neighboring gene metadherin pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:64428091-64428834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:64428835-64429578 Neighboring gene MPRA-validated peak6534 silencer Neighboring gene vomeronasal 1 receptor 43 pseudogene Neighboring gene zinc finger protein 117 Neighboring gene Sharpr-MPRA regulatory region 12375 Neighboring gene endogenous retrovirus group 3 member 1, envelope Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18197 Neighboring gene uncharacterized LOC105375330 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:64480738-64480945 Neighboring gene uncharacterized LOC105375329 Neighboring gene RNA, U6 small nuclear 1229, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. Kato N, et al. Mol Cell Biol, 1990 Aug. PMID 2115127, Free PMC Article
  2. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. Bellefroid EJ, et al. DNA, 1989 Jul-Aug. PMID 2505992
  3. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1991 May 1. PMID 2023909, Free PMC Article
  4. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
  5. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 117
Names
provirus-linked krueppel
zinc finger protein HPF9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348050.2 → NP_001334979.1  zinc finger protein 117

    Status: VALIDATED

    Source sequence(s)
    AC073210
    UniProtKB/Swiss-Prot
    Q02313, Q03924, Q7Z7Q7
    Related
    ENSP00000519316.1, ENST00000714026.1
    Conserved Domains (2) summary
    COG5048
    Location:163 → 475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:279 → 299
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    64971776..65006746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    66177979..66212924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03924.5 GenPept UniProtKB/Swiss-Prot:Q03924

Gene LinkOut

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Molecular Biology Databases
Research Materials