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Txlna taxilin alpha [ Mus musculus (house mouse) ]

Gene ID: 109658, updated on 28-Oct-2024

Summary

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Official Symbol
Txlnaprovided by MGI
Official Full Name
taxilin alphaprovided by MGI
Primary source
MGI:MGI:105968
See related
Ensembl:ENSMUSG00000053841 AllianceGenome:MGI:105968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il14; Txln; 2600010N21Rik
Summary
Predicted to enable syntaxin binding activity. Acts upstream of or within B cell activation. Predicted to be located in cytoplasm. Is expressed in brain; metanephros; oviduct; spinal cord; and testis. Orthologous to human TXLNA (taxilin alpha). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 25.6), CNS E11.5 (RPKM 25.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Txlna in Genome Data Viewer
Location:
4 D2.2; 4 63.26 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129519870..129534867, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129626077..129641065, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10261 Neighboring gene STARR-seq mESC enhancer starr_11504 Neighboring gene IQ motif containing C Neighboring gene coiled coil domain containing 28B Neighboring gene predicted gene, 34305 Neighboring gene STARR-positive B cell enhancer ABC_E1283 Neighboring gene karyopherin subunit alpha 6 Neighboring gene STARR-positive B cell enhancer ABC_E7992 Neighboring gene transmembrane protein 39b Neighboring gene microRNA 7016

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice. Le Goff L, et al. Int J Parasitol, 2002 Sep. PMID 12204227
  2. IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans. Shen L, et al. Clin Immunol, 2009 Mar. PMID 19038581
  3. Characteristics of a novel monoclonal antibody against interleukin-14alpha. Peng X, et al. Hybridoma (Larchmt), 2009 Aug. PMID 19663695
  4. Unexpected requirement for a binding partner of the syntaxin family in phagocytosis by murine testicular Sertoli cells. Dong YS, et al. Cell Death Differ, 2016 May. PMID 26494466, Free PMC Article
  5. Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway. Jin X, et al. Aging Cell, 2020 Oct. PMID 32840323, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway.
    Title: Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway.
  2. The TXLNA may serve as an important feedback mechanism to modulate the magnitude of subsequent phagocytotic process of SCs in response to testicular injury.
    Title: Unexpected requirement for a binding partner of the syntaxin family in phagocytosis by murine testicular Sertoli cells.
  3. analysis of a novel monoclonal antibody against interleukin-14alpha
    Title: Characteristics of a novel monoclonal antibody against interleukin-14alpha.
  4. Transgenic mice in which IL-14a expression was increased constitutively develop all the clinical and immunological features of primary Sjogren's disease in the same relative time frame as patients with primary Sjogren's disease
    Title: IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC77972, MGC86145

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-taxilin
Names
interleukin 14
taxilin Txln

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005506.3 → NP_001005506.2  alpha-taxilin

    See identical proteins and their annotated locations for NP_001005506.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK168418, AW121192, BC060227
    Consensus CDS
    CCDS38887.1
    UniProtKB/Swiss-Prot
    Q6P1E5, Q6PAM1
    UniProtKB/TrEMBL
    Q3UD58
    Related
    ENSMUSP00000081285.6, ENSMUST00000084264.12
    Conserved Domains (1) summary
    pfam09728
    Location:170 → 477
    Taxilin; Myosin-like coiled-coil protein

  2. NM_001199695.1 → NP_001186624.1  alpha-taxilin

    See identical proteins and their annotated locations for NP_001186624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK150240, AW121192, CJ151043
    Consensus CDS
    CCDS38887.1
    UniProtKB/Swiss-Prot
    Q6P1E5, Q6PAM1
    UniProtKB/TrEMBL
    Q3UD58
    Related
    ENSMUSP00000042153.10, ENSMUST00000046425.16
    Conserved Domains (1) summary
    pfam09728
    Location:170 → 477
    Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129519870..129534867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502659.5 → XP_006502722.1  alpha-taxilin isoform X1

    See identical proteins and their annotated locations for XP_006502722.1

    UniProtKB/Swiss-Prot
    Q6P1E5, Q6PAM1
    UniProtKB/TrEMBL
    Q3UD58
    Conserved Domains (1) summary
    pfam09728
    Location:170 → 477
    Taxilin; Myosin-like coiled-coil protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PAM1.1 GenPept UniProtKB/Swiss-Prot:Q6PAM1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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