Htd2 hydroxyacyl-thioester dehydratase type 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htd2provided by MGI
Official Full Name: hydroxyacyl-thioester dehydratase type 2provided by MGI
Primary source: MGI:MGI:5827763
See related: Ensembl:ENSMUSG00000023156 AllianceGenome:MGI:5827763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within lipoate biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 14 A1; 14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (14377937..14389436, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (8080313..8091846)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Htd2 deficiency-associated suppression of alpha-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes.
Title: Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes.

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General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipoate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hydroxyacyl-thioester dehydratase type 2, mitochondrial

NP_001335656.1

EC 4.2.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348727.2 → NP_001335656.1 hydroxyacyl-thioester dehydratase type 2, mitochondrial

Status: VALIDATED

Source sequence(s)

AC139029

Consensus CDS

CCDS88564.1

UniProtKB/TrEMBL

J3QMX0

Related

ENSMUSP00000136494.2, ENSMUST00000180369.2

Conserved Domains (1) summary

cd03449
Location:27 → 152

R_hydratase; (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase ...