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Zbtb25 zinc finger and BTB domain containing 25 [ Mus musculus (house mouse) ]

Gene ID: 109929, updated on 2-Nov-2024

Summary

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Official Symbol
Zbtb25provided by MGI
Official Full Name
zinc finger and BTB domain containing 25provided by MGI
Primary source
MGI:MGI:99197
See related
Ensembl:ENSMUSG00000056459 AllianceGenome:MGI:99197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kup; Zfp50; Zfp-50; 2810462M08Rik; 2900064P18Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in genitourinary system. Orthologous to human ZBTB25 (zinc finger and BTB domain containing 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 3.3), limb E14.5 (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb25 in Genome Data Viewer
Location:
12 C3; 12 33.73 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76387168..76416988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76348900..76370214, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Neighboring gene predicted gene, 40443 Neighboring gene A kinase anchor protein 5 Neighboring gene STARR-seq mESC enhancer starr_32516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468237-77468545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468685-77468794 Neighboring gene RIKEN cDNA 4930426I24 gene Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E94 Neighboring gene STARR-seq mESC enhancer starr_32522 Neighboring gene heat shock protein 2 Neighboring gene protein phosphatase 1, regulatory subunit 36 Neighboring gene predicted gene, 25563

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. Chardin P, et al. Nucleic Acids Res, 1991 Apr 11. PMID 2027750, Free PMC Article
  2. Refinement of the DNA marker maps of mouse chromosome 12. Khan F, et al. Genomics, 1994 May 1. PMID 8088780
  3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 25
Names
zinc finger protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172104.1 → NP_001165575.1  zinc finger and BTB domain-containing protein 25

    See identical proteins and their annotated locations for NP_001165575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124453
    Consensus CDS
    CCDS25991.2
    UniProtKB/TrEMBL
    G3UW50
    Related
    ENSMUSP00000128471.2, ENSMUST00000167011.8
    Conserved Domains (3) summary
    sd00018
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

  2. NM_028356.2 → NP_082632.2  zinc finger and BTB domain-containing protein 25

    See identical proteins and their annotated locations for NP_082632.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124453
    Consensus CDS
    CCDS25991.2
    UniProtKB/TrEMBL
    G3UW50
    Related
    ENSMUSP00000134748.2, ENSMUST00000176278.8
    Conserved Domains (3) summary
    sd00018
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76387168..76416988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314936.3 → XP_017170425.2  zinc finger and BTB domain-containing protein 25 isoform X3

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126 → 148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128 → 148
    zf-C2H2; Zinc finger, C2H2 type

  2. XM_006515397.3 → XP_006515460.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515460.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

  3. XM_030246520.2 → XP_030102380.1  zinc finger and BTB domain-containing protein 25 isoform X3

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126 → 148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128 → 148
    zf-C2H2; Zinc finger, C2H2 type

  4. XM_030246517.2 → XP_030102377.1  zinc finger and BTB domain-containing protein 25 isoform X2

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

  5. XM_030246519.2 → XP_030102379.1  zinc finger and BTB domain-containing protein 25 isoform X3

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126 → 148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128 → 148
    zf-C2H2; Zinc finger, C2H2 type

  6. XM_006515396.3 → XP_006515459.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515459.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

  7. XM_030246518.2 → XP_030102378.1  zinc finger and BTB domain-containing protein 25 isoform X3

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126 → 148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128 → 148
    zf-C2H2; Zinc finger, C2H2 type

  8. XM_006515400.3 → XP_006515463.1  zinc finger and BTB domain-containing protein 25 isoform X3

    See identical proteins and their annotated locations for XP_006515463.1

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126 → 148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128 → 148
    zf-C2H2; Zinc finger, C2H2 type

  9. XM_006515394.3 → XP_006515457.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515457.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

  10. XM_006515393.3 → XP_006515456.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515456.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

  11. XM_030246516.2 → XP_030102376.1  zinc finger and BTB domain-containing protein 25 isoform X2

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

  12. XM_006515399.3 → XP_006515462.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515462.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3 → 130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

  13. XM_006515392.5 → XP_006515455.1  zinc finger and BTB domain-containing protein 25 isoform X1

    Conserved Domains (5) summary
    smart00355
    Location:548 → 568
    ZnF_C2H2; zinc finger
    PHA03307
    Location:2 → 250
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00018
    Location:432 → 454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434 → 454
    zf-C2H2; Zinc finger, C2H2 type
    cl38908
    Location:249 → 323
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
Nucleotide Protein Strain
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