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LOC110121318 VISTA enhancer hs1056 [ Homo sapiens (human) ]

Gene ID: 110121318, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110121318
Gene description
VISTA enhancer hs1056
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents a conserved genomic element that can function as an enhancer. The major subregion can activate a Hsp68 promoter coupled to a LacZ reporter gene in embryonic forebrain, midbrain and neural tube of transgenic mice. Two subregions marked by the H3K4me1 histone modification were also shown to be active enhancers by ChIP-STARR-seq in primed human embryonic stem cells. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC110121318 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (78721722..78723806)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (78955775..78957863)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (76481722..76483257)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76399811-76400311 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:76406811-76408010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76419597-76420098 Neighboring gene uncharacterized LOC124904330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76447079-76447994 Neighboring gene VISTA enhancer hs1011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76480426-76481346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76528785-76529642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76539929-76540887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76547900-76548400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76548401-76548901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76569491-76569992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76569993-76570492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76573303-76573813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76589119-76589625 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:76610953-76612152 Neighboring gene uncharacterized LOC105372224 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:76669815-76671014 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:76686389-76687588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76694205-76695173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76695174-76696141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76707071-76707585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76732217-76732814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:76732815-76733411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:76736667-76737380 Neighboring gene long intergenic non-protein coding RNA 1896

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VISTA Enhancer Browser--a database of tissue-specific human enhancers. Visel A, et al. Nucleic Acids Res, 2007 Jan. PMID 17130149, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • H3K4me1 hESC enhancer GRCh37_chr18:76482612-76483209
  • H3K4me1 hESC enhancer GRCh37_chr18:76483210-76483806

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053933.2 

    Range
    101..2185
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    78721722..78723806
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    78955775..78957863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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