LOC110366354 CYP3A4 5' regulatory region [Homo sapiens (human)] - Gene

Summary

Gene symbol: LOC110366354
Gene description: CYP3A4 5' regulatory region
Gene type: biological region
Feature type(s): protein_bind
regulatory: enhancer, promoter, silencer, transcriptional_cis_regulatory_region
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLEM; XREM
Summary: This record represents the 5' regulatory region of the cytochrome P450 family 3 subfamily A member 4 gene. This sequence includes the proximal promoter as well as multiple enhancer modules present within the 12 kb upstream region. Xenobiotics, including rifampicin, induce activity of this regulatory region, as do vitamin D and glucocorticoids. The promoter and distal enhancers contain response elements that are stimulated by binding of nuclear receptor subfamily 1 group I member 2 (Nr1i2/Pxr) dimerized with retinoid X receptor alpha. These sites may also binds other nuclear receptors, thyroid receptor, and vitamin D receptor, which may positively regulate expression or compete with Nr1i2/Pxr binding and induction. This region is also regulated by binding of CCAAT/enhancer binding protein and hepatocyte nuclear factor 4 to defined recognition sites. [provided by RefSeq, May 2017]
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Genomic context

Location:: chromosome: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (99784132..99796700)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (101023631..101036213)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (99381755..99394323)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

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General gene information

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Other Names

CYP3A4 promoter
constitutive liver enhancer module of CYP3A4
xenobiotic responsive element module

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.