Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search NCBI

LOC110599580 - CYP1B1 promoter

This region represents the promoter of the cytochrome P450 family 1 subfamily B member 1 (CYP1B1) gene. This promoter is stimulated by xenobiotics such as TCDD through binding of aryl hydrocarbon receptor and Sp1 transcription factor to multiple sequence motifs in this region. Estradiol also activates this promoter through binding of estrogen receptor. A naturally-occurring polymorphism in the proximal promoter region (rs2567206) was shown to affect promoter activity and is associated with glaucoma. This region may be silenced by DNA methylation in cancers. This locus also includes two accessible chromatin subregions that were validated as silencers based on their ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]

Genes similar to LOC110599580

NCBI Orthologs

How was this calculated?

genes for:

Protein alignment

Align

Download data

Download
Species Gene Architecture aa