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DEPP1 DEPP autophagy regulator 1 [ Homo sapiens (human) ]

Gene ID: 11067, updated on 4-Jan-2025

Summary

Official Symbol
DEPP1provided by HGNC
Official Full Name
DEPP autophagy regulator 1provided by HGNC
Primary source
HGNC:HGNC:23355
See related
Ensembl:ENSG00000165507 MIM:611309; AllianceGenome:HGNC:23355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIG; DEPP; Fseg; C10orf10
Summary
The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 86.3), endometrium (RPKM 51.4) and 24 other tissues See more
Orthologs
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Genomic context

See DEPP1 in Genome Data Viewer
Location:
10q11.21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (44976128..44978809, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (45857092..45859773, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45471576..45474257, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene TMEM72 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:45413376-45413557 Neighboring gene transmembrane protein 72 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45427808-45428515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45428516-45429222 Neighboring gene Sharpr-MPRA regulatory region 7362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3314 Neighboring gene Sharpr-MPRA regulatory region 11970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3318 Neighboring gene Sharpr-MPRA regulatory region 2327 Neighboring gene uncharacterized LOC105378281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45467973-45468635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45468636-45469297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45470934-45471637 Neighboring gene Ras association domain family member 4 Neighboring gene Sharpr-MPRA regulatory region 8316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475153-45475856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475857-45476558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45479350-45479850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45486450-45487141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487171-45487672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487673-45488172 Neighboring gene uncharacterized LOC124902530 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:45496487-45496987 Neighboring gene ZNF22 antisense RNA 1 Neighboring gene zinc finger protein 22

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in autophagy  
involved_in regulation of autophagy  
involved_in regulation of autophagy PubMed 
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in intracellular membrane-bounded organelle  
is_active_in mitochondrion  
located_in mitochondrion PubMed 
located_in peroxisome PubMed 

General protein information

Preferred Names
protein DEPP1
Names
DEPP1 autophagy regulator
decidual protein induced by progesterone
fasting induced
fasting-induced gene protein
fasting-induced protein
fat-specific expressed
protein DEPP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007021.4NP_008952.1  protein DEPP1

    See identical proteins and their annotated locations for NP_008952.1

    Status: REVIEWED

    Source sequence(s)
    AL353801, DB030770
    Consensus CDS
    CCDS7210.1
    UniProtKB/Swiss-Prot
    B2R6A1, O94997, Q5T735, Q76MX8, Q9NTK1
    Related
    ENSP00000298295.3, ENST00000298295.4
    Conserved Domains (1) summary
    pfam15343
    Location:25212
    DEPP; Decidual protein induced by progesterone family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    44976128..44978809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    45857092..45859773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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