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MNS16A MNS16A minisatellite promoter [ Homo sapiens (human) ]

Gene ID: 110806265, updated on 17-Sep-2024

Summary

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Gene symbol
MNS16A
Gene description
MNS16A minisatellite promoter
Gene type
biological region
Feature type(s)
regulatory: promoter
repeat_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents a promoter located downstream of the telomerase reverse transcriptase (TERT) gene. This sequence contains a VNTR (variable number tandem repeat) minisatellite sequence that may be associated with cancer risk. [provided by RefSeq, Aug 2017]
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Genomic context

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See MNS16A in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (1252328..1252986)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (1159235..1159893)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1252443..1253101)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1204178-1204741 Neighboring gene solute carrier family 6 member 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1225890-1226432 Neighboring gene solute carrier family 6 member 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1264322-1264939 Neighboring gene telomerase reverse transcriptase Neighboring gene Sharpr-MPRA regulatory region 13256 Neighboring gene TERT enhancer in intron 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1290609-1291360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1291361-1292111 Neighboring gene TERT 5' regulatory region Neighboring gene microRNA 4457

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MNS16A tandem repeat minisatellite of human telomerase gene: functional studies in colorectal, lung and prostate cancer. Hofer P, et al. Oncotarget, 2017 Apr 25. PMID 28427205, Free PMC Article
  2. MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis. Xia X, et al. PLoS One, 2013. PMID 23991190, Free PMC Article
  3. MNS16A tandem repeat minisatellite of human telomerase gene and prostate cancer susceptibility. Hofer P, et al. Mutagenesis, 2013 May. PMID 23423318
  4. MNS16A polymorphism of the TERT gene on cancer risk: a systematic review and meta-analysis. Yuan H, et al. Nucleosides Nucleotides Nucleic Acids, 2023. PMID 37345793
  5. Role of the functional MNS16A VNTR-243 variant of the human telomerase reverse transcriptase gene in progression and response to therapy of patients with non-Hodgkin's B-cell lymphomas. Wysoczanska B, et al. Int J Immunogenet, 2015 Apr. PMID 25684018

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MNS16A polymorphism of the TERT gene on cancer risk: a systematic review and meta-analysis.
    Title: MNS16A polymorphism of the TERT gene on cancer risk: a systematic review and meta-analysis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055469.1 

    Range
    101..759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    1252328..1252986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    1159235..1159893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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