U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PTPN21 protein tyrosine phosphatase non-receptor type 21 [ Homo sapiens (human) ]

Gene ID: 11099, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
PTPN21provided by HGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 21provided by HGNC
Primary source
HGNC:HGNC:9651
See related
Ensembl:ENSG00000070778 MIM:603271; AllianceGenome:HGNC:9651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPD1; PTPRL10
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 8.6), lung (RPKM 8.5) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PTPN21 in Genome Data Viewer
Location:
14q31.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88465778..88555007, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82686590..82775829, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88932122..89021351, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984699 Neighboring gene uncharacterized LOC105370612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5989 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38654 Neighboring gene Sharpr-MPRA regulatory region 1231 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:88685623-88685838 Neighboring gene potassium two pore domain channel subfamily K member 10 Neighboring gene Sharpr-MPRA regulatory region 1180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:88788959-88789618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:88792556-88793070 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:88830965-88831772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8840 Neighboring gene spermatogenesis associated 7 Neighboring gene NANOG hESC enhancer GRCh37_chr14:88948745-88949275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8841 Neighboring gene uncharacterized LOC105370614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89015655-89016472 Neighboring gene RNA, U4 small nuclear 22, pseudogene Neighboring gene proline-rich protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:89084698-89085319 Neighboring gene zinc finger CCCH-type containing 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8843 Neighboring gene EMAP like 5 Neighboring gene MPRA-validated peak2226 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5994 Neighboring gene RNA, U4 small nuclear 92, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular Analysis of the Interaction between Human PTPN21 and the Oncoprotein E7 from Human Papillomavirus Genotype 18. Lee HS, et al. Mol Cells, 2021 Jan 31. PMID 33431714, Free PMC Article
  2. PTPN21-CDS(long) isoform inhibits the response of acute lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I axis. Wang H, et al. J Cell Biochem, 2020 Jun. PMID 31898344
  3. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Chen J, et al. Schizophr Res, 2011 Sep. PMID 21752600, Free PMC Article
  4. Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Zeitlin AA, et al. Clin Endocrinol (Oxf), 2006 Sep. PMID 16918960
  5. Expression of protein tyrosine phosphatase PTP-RL10 and its isoform in the mouse testis. Tokuchi H, et al. Int J Urol, 1999 Nov. PMID 10585123

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Analysis of the Interaction between Human PTPN21 and the Oncoprotein E7 from Human Papillomavirus Genotype 18.
    Title: Molecular Analysis of the Interaction between Human PTPN21 and the Oncoprotein E7 from Human Papillomavirus Genotype 18.
  2. PTPN21-CDSlong isoform inhibits the response of acute lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I axis.
    Title: PTPN21-CDS(long) isoform inhibits the response of acute lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I axis.
  3. Study demonstrates that PTPN21 activates KIF1C by binding to the stalk region. This function does not require catalytic activity of the phosphatase, and its N-terminal FERM domain alone is sufficient to stimulate the transport of KIF1C cargoes in cells as well as increasing the landing rate of KIF1C on microtubules in vitro. The cargo adapter Hook3 binds KIF1C in the same region and activates KIF1C in a similar way.
    Title: PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
  4. Presented data suggest that the transient formation of dynamic PTPD1/EGFR signalling complexes strengthens EGF signalling by promoting the spatial propagation of EGFR phosphorylated species
    Title: Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation.
  5. The results that 2 non-synonymous markers in PTPN21 are associated with schizophrenia, further investigation of this locus is warranted.
    Title: Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia.
  6. PTPD1 is a novel component of the endocytic machinery that impacts on EGF receptor stability and on growth and motility of bladder cancer cells
    Title: PTPD1 supports receptor stability and mitogenic signaling in bladder cancer cells.
  7. In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency; the highest mutation frequency among 16 PTP genes
    Title: Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
  8. PTPD1 is a component of a multivalent scaffold complex nucleated by FAK at specific intracellular sites
    Title: Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein phosphatase non-receptor type 21
Names
dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)
protein-tyrosine phosphatase D1
NP_008970.2
XP_005267344.1
XP_011534669.1
XP_011534670.1
XP_016876428.1
XP_054231261.1
XP_054231262.1
XP_054231263.1
XP_054231264.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046949.1 RefSeqGene

    Range
    4773..94002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007039.4 → NP_008970.2  tyrosine-protein phosphatase non-receptor type 21

    See identical proteins and their annotated locations for NP_008970.2

    Status: REVIEWED

    Source sequence(s)
    AL049834, AL162171, BM930068, DA860560, X79510
    Consensus CDS
    CCDS9884.1
    UniProtKB/Swiss-Prot
    Q16825
    UniProtKB/TrEMBL
    Q8WX29
    Related
    ENSP00000452414.1, ENST00000556564.6
    Conserved Domains (6) summary
    smart00194
    Location:896 → 1166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:923 → 1166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:217 → 307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:109 → 220
    FERM_M; FERM central domain
    pfam09379
    Location:27 → 90
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    88465778..88555007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267287.4 → XP_005267344.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

    See identical proteins and their annotated locations for XP_005267344.1

    UniProtKB/Swiss-Prot
    Q16825
    UniProtKB/TrEMBL
    Q8WX29
    Related
    ENSP00000330276.3, ENST00000328736.7
    Conserved Domains (6) summary
    smart00194
    Location:896 → 1166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:923 → 1166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:217 → 307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:109 → 220
    FERM_M; FERM central domain
    pfam09379
    Location:27 → 90
    FERM_N; FERM N-terminal domain

  2. XM_011536367.4 → XP_011534669.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

    See identical proteins and their annotated locations for XP_011534669.1

    UniProtKB/Swiss-Prot
    Q16825
    UniProtKB/TrEMBL
    Q8WX29
    Conserved Domains (6) summary
    smart00194
    Location:896 → 1166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:923 → 1166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:217 → 307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:109 → 220
    FERM_M; FERM central domain
    pfam09379
    Location:27 → 90
    FERM_N; FERM N-terminal domain

  3. XM_011536368.3 → XP_011534670.1  tyrosine-protein phosphatase non-receptor type 21 isoform X2

    See identical proteins and their annotated locations for XP_011534670.1

    UniProtKB/TrEMBL
    Q8WX29
    Conserved Domains (4) summary
    smart00194
    Location:773 → 1043
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:800 → 1043
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:94 → 184
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:27 → 97
    FERM_M; FERM central domain

  4. XM_017020939.2 → XP_016876428.1  tyrosine-protein phosphatase non-receptor type 21 isoform X3

    UniProtKB/TrEMBL
    Q8WX29
    Conserved Domains (3) summary
    smart00194
    Location:692 → 962
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:719 → 962
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:13 → 103
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    82686590..82775829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375286.1 → XP_054231261.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

    UniProtKB/Swiss-Prot
    Q16825

  2. XM_054375287.1 → XP_054231262.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

    UniProtKB/Swiss-Prot
    Q16825

  3. XM_054375288.1 → XP_054231263.1  tyrosine-protein phosphatase non-receptor type 21 isoform X2

  4. XM_054375289.1 → XP_054231264.1  tyrosine-protein phosphatase non-receptor type 21 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16825.2 GenPept UniProtKB/Swiss-Prot:Q16825

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous