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ATE1 arginyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 11101, updated on 7-Apr-2024

Summary

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Official Symbol
ATE1provided by HGNC
Official Full Name
arginyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:782
See related
Ensembl:ENSG00000107669 MIM:607103; AllianceGenome:HGNC:782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in thyroid (RPKM 8.9), testis (RPKM 7.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ATE1 in Genome Data Viewer
Location:
10q26.13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (121740424..121928463, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (122636555..122824802, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123499939..123687978, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123383269-123383770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123383771-123384270 Neighboring gene uncharacterized LOC107984183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123403785-123404286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:123427853-123428402 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:123428403-123428952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123441905-123442847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123455553-123456052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123455051-123455552 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:123492224-123492816 Neighboring gene ribosomal protein S15a pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4141 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123687446-123688312 Neighboring gene Sharpr-MPRA regulatory region 2750 Neighboring gene ATE1 antisense RNA 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:123734371-123735166 Neighboring gene uncharacterized LOC124902517 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:123778189-123779388 Neighboring gene transforming acidic coiled-coil containing protein 2 Neighboring gene Sharpr-MPRA regulatory region 10515 Neighboring gene Sharpr-MPRA regulatory regions 8460 and 2354 Neighboring gene MPRA-validated peak1120 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123836619-123837120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123844981-123845482 Neighboring gene Sharpr-MPRA regulatory regions 1076 and 11287 Neighboring gene uncharacterized LOC124902518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123914119-123915090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling. Xu C, et al. Mol Cancer Res, 2021 Sep. PMID 34158395, Free PMC Article
  2. Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene. Kalinina M, et al. Nucleic Acids Res, 2021 Jan 11. PMID 33330934, Free PMC Article
  3. Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core. Kishimoto N, et al. Retrovirology, 2021 Sep 26. PMID 34565409, Free PMC Article
  4. Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis. Birnbaum MD, et al. Oncogene, 2019 Feb. PMID 30177837, Free PMC Article
  5. Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers. Rai R, et al. Oncogene, 2016 Aug 4. PMID 26686093, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/beta-Catenin Signaling.
    Title: ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling.
  2. The Final Maturation State of beta-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
    Title: The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
  3. Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core.
    Title: Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core.
  4. Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene.
    Title: Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene.
  5. study revealed a novel role of Ate1 in suppressing prostate cancer metastasis, which has a profound significance for establishing metastatic indicators for prostate cancer, and for finding potential treatments to prevent its metastasis.
    Title: Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis.
  6. Ate1 is downregulated in several types of human cancer samples at the protein level, and that its transcription level inversely correlates with metastatic progression and patient survival.
    Title: Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers.
  7. Data indicate that arginyltransferase 1 (ATE1) function controls Myocardin-related transcription factor A (MRTF-A) activity.
    Title: Inhibition of arginyltransferase 1 induces transcriptional activity of myocardin-related transcription factor A (MRTF-A) and promotes directional migration.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arginyl-tRNA--protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginyl-tRNA--protein transferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein arginylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein arginylation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arginyl-tRNA--protein transferase 1
Names
R-transferase 1
arginine-tRNA--protein transferase 1
arginyl-tRNA-protein transferase
NP_001001976.1
NP_001275663.1
NP_001275664.1
NP_001275665.1
NP_008972.2
XP_005269515.1
XP_005269516.1
XP_016871086.2
XP_016871087.1
XP_016871088.1
XP_016871090.2
XP_016871092.2
XP_047280477.1
XP_047280478.1
XP_047280479.1
XP_047280480.1
XP_047280481.1
XP_047280482.1
XP_047280483.1
XP_047280484.1
XP_047280485.1
XP_047280486.1
XP_047280487.1
XP_047280488.1
XP_047280489.1
XP_047280490.1
XP_047280491.1
XP_047280492.1
XP_054220606.1
XP_054220607.1
XP_054220608.1
XP_054220609.1
XP_054220610.1
XP_054220611.1
XP_054220612.1
XP_054220613.1
XP_054220614.1
XP_054220615.1
XP_054220616.1
XP_054220617.1
XP_054220618.1
XP_054220619.1
XP_054220620.1
XP_054220621.1
XP_054220622.1
XP_054220623.1
XP_054220624.1
XP_054220625.1
XP_054220626.1
XP_054220627.1
XP_054220628.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001976.3 → NP_001001976.1  arginyl-tRNA--protein transferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001001976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC025947, AL731542, AL731566
    Consensus CDS
    CCDS31300.1
    UniProtKB/Swiss-Prot
    O95260, O95261, Q5SQQ3, Q8WW04
    UniProtKB/TrEMBL
    A0A8I5KZ28
    Related
    ENSP00000224652.6, ENST00000224652.12
    Conserved Domains (2) summary
    pfam04376
    Location:21 → 92
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:290 → 431
    ATE_C; Arginine-tRNA-protein transferase, C terminus

  2. NM_001288734.2 → NP_001275663.1  arginyl-tRNA--protein transferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001275663.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC025947, AL731542, AL731566
    UniProtKB/TrEMBL
    A0A8I5QKV3, B4DK25
    Conserved Domains (1) summary
    pfam04377
    Location:175 → 316
    ATE_C; Arginine-tRNA-protein transferase, C terminus

  3. NM_001288735.2 → NP_001275664.1  arginyl-tRNA--protein transferase 1 isoform 4

    See identical proteins and their annotated locations for NP_001275664.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, initiates translation at a downstream start codon, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AC025947, AL731542, AL731566
    UniProtKB/TrEMBL
    A0A8I5QKV3, B4E107
    Related
    ENSP00000509714.1, ENST00000693276.1
    Conserved Domains (1) summary
    pfam04377
    Location:198 → 335
    ATE_C; Arginine-tRNA-protein transferase, C terminus

  4. NM_001288736.2 → NP_001275665.1  arginyl-tRNA--protein transferase 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) has a shorter and distinct N-terminus and a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AC025947, AL731542, AL731566
    Consensus CDS
    CCDS73213.1
    UniProtKB/TrEMBL
    B4DR48, F5GXE4
    Related
    ENSP00000440881.1, ENST00000540606.7
    Conserved Domains (2) summary
    pfam04376
    Location:14 → 85
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:287 → 424
    ATE_C; Arginine-tRNA-protein transferase, C terminus

  5. NM_007041.4 → NP_008972.2  arginyl-tRNA--protein transferase 1 isoform 2

    See identical proteins and their annotated locations for NP_008972.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1 but has a unique internal segment.
    Source sequence(s)
    AC025947, AL731542, AL731566
    Consensus CDS
    CCDS31299.1
    UniProtKB/TrEMBL
    A0A8I5KNT9
    Related
    ENSP00000358039.3, ENST00000369043.8
    Conserved Domains (2) summary
    pfam04376
    Location:21 → 92
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:294 → 431
    ATE_C; Arginine-tRNA-protein transferase, C terminus

RNA

  1. NR_110006.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5'-terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC025947, AL731542, AL731566
    Related
    ENST00000692718.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    121740424..121928463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424532.1 → XP_047280488.1  arginyl-tRNA--protein transferase 1 isoform X16

  2. XM_047424530.1 → XP_047280486.1  arginyl-tRNA--protein transferase 1 isoform X13

  3. XM_017015598.3 → XP_016871087.1  arginyl-tRNA--protein transferase 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I5KNV5, A0A8I5KTH0, B4DR48
    Related
    ENSP00000509590.1, ENST00000689571.1

  4. XM_047424523.1 → XP_047280479.1  arginyl-tRNA--protein transferase 1 isoform X6

  5. XM_005269459.4 → XP_005269516.1  arginyl-tRNA--protein transferase 1 isoform X4

    UniProtKB/TrEMBL
    B4DR48
    Conserved Domains (2) summary
    pfam04376
    Location:14 → 85
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:330 → 467
    ATE_C; Arginine-tRNA-protein transferase, C terminus

  6. XM_017015599.3 → XP_016871088.1  arginyl-tRNA--protein transferase 1 isoform X15

    UniProtKB/TrEMBL
    A0A8I5KNT9, A0A8I5KZ28, F8WAC9
    Related
    ENSP00000358036.4, ENST00000369040.9

  7. XM_047424529.1 → XP_047280485.1  arginyl-tRNA--protein transferase 1 isoform X12

  8. XM_047424522.1 → XP_047280478.1  arginyl-tRNA--protein transferase 1 isoform X5

  9. XM_005269458.4 → XP_005269515.1  arginyl-tRNA--protein transferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KZ24, A0A8I5KZ28
    Related
    ENSP00000510433.1, ENST00000690355.1
    Conserved Domains (2) summary
    pfam04376
    Location:21 → 92
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:337 → 474
    ATE_C; Arginine-tRNA-protein transferase, C terminus

  10. XM_047424527.1 → XP_047280483.1  arginyl-tRNA--protein transferase 1 isoform X9

    Related
    ENSP00000510033.1, ENST00000692278.1

  11. XM_047424525.1 → XP_047280481.1  arginyl-tRNA--protein transferase 1 isoform X8

    Related
    ENSP00000509487.1, ENST00000689393.1

  12. XM_017015597.2 → XP_016871086.2  arginyl-tRNA--protein transferase 1 isoform X2

  13. XM_047424521.1 → XP_047280477.1  arginyl-tRNA--protein transferase 1 isoform X1

  14. XM_047424528.1 → XP_047280484.1  arginyl-tRNA--protein transferase 1 isoform X10

  15. XM_047424524.1 → XP_047280480.1  arginyl-tRNA--protein transferase 1 isoform X7

    Related
    ENSP00000508420.1, ENST00000691573.1

  16. XM_047424531.1 → XP_047280487.1  arginyl-tRNA--protein transferase 1 isoform X14

  17. XM_047424526.1 → XP_047280482.1  arginyl-tRNA--protein transferase 1 isoform X9

  18. XM_047424533.1 → XP_047280489.1  arginyl-tRNA--protein transferase 1 isoform X17

  19. XM_017015603.2 → XP_016871092.2  arginyl-tRNA--protein transferase 1 isoform X19

  20. XM_047424536.1 → XP_047280492.1  arginyl-tRNA--protein transferase 1 isoform X22

    Related
    ENSP00000509863.1, ENST00000687251.1

  21. XM_047424534.1 → XP_047280490.1  arginyl-tRNA--protein transferase 1 isoform X20

  22. XM_017015601.3 → XP_016871090.2  arginyl-tRNA--protein transferase 1 isoform X18

  23. XM_047424535.1 → XP_047280491.1  arginyl-tRNA--protein transferase 1 isoform X21

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    122636555..122824802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364647.1 → XP_054220622.1  arginyl-tRNA--protein transferase 1 isoform X16

  2. XM_054364644.1 → XP_054220619.1  arginyl-tRNA--protein transferase 1 isoform X13

  3. XM_054364642.1 → XP_054220617.1  arginyl-tRNA--protein transferase 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I5KTH0

  4. XM_054364636.1 → XP_054220611.1  arginyl-tRNA--protein transferase 1 isoform X6

  5. XM_054364634.1 → XP_054220609.1  arginyl-tRNA--protein transferase 1 isoform X4

  6. XM_054364646.1 → XP_054220621.1  arginyl-tRNA--protein transferase 1 isoform X15

    UniProtKB/TrEMBL
    F8WAC9

  7. XM_054364643.1 → XP_054220618.1  arginyl-tRNA--protein transferase 1 isoform X12

  8. XM_054364635.1 → XP_054220610.1  arginyl-tRNA--protein transferase 1 isoform X5

  9. XM_054364633.1 → XP_054220608.1  arginyl-tRNA--protein transferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KZ24

  10. XM_054364640.1 → XP_054220615.1  arginyl-tRNA--protein transferase 1 isoform X9

  11. XM_054364638.1 → XP_054220613.1  arginyl-tRNA--protein transferase 1 isoform X8

  12. XM_054364632.1 → XP_054220607.1  arginyl-tRNA--protein transferase 1 isoform X2

  13. XM_054364631.1 → XP_054220606.1  arginyl-tRNA--protein transferase 1 isoform X1

  14. XM_054364637.1 → XP_054220612.1  arginyl-tRNA--protein transferase 1 isoform X7

  15. XM_054364645.1 → XP_054220620.1  arginyl-tRNA--protein transferase 1 isoform X14

  16. XM_054364641.1 → XP_054220616.1  arginyl-tRNA--protein transferase 1 isoform X10

  17. XM_054364639.1 → XP_054220614.1  arginyl-tRNA--protein transferase 1 isoform X9

  18. XM_054364648.1 → XP_054220623.1  arginyl-tRNA--protein transferase 1 isoform X17

  19. XM_054364650.1 → XP_054220625.1  arginyl-tRNA--protein transferase 1 isoform X19

  20. XM_054364653.1 → XP_054220628.1  arginyl-tRNA--protein transferase 1 isoform X26

  21. XM_054364651.1 → XP_054220626.1  arginyl-tRNA--protein transferase 1 isoform X24

  22. XM_054364649.1 → XP_054220624.1  arginyl-tRNA--protein transferase 1 isoform X23

  23. XM_054364652.1 → XP_054220627.1  arginyl-tRNA--protein transferase 1 isoform X25

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95260.2 GenPept UniProtKB/Swiss-Prot:O95260

Gene LinkOut

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