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Hoxd homeobox D cluster [ Mus musculus (house mouse) ]

Gene ID: 111337, updated on 28-May-2024

Summary

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Official Symbol
Hoxdprovided by MGI
Official Full Name
homeobox D clusterprovided by MGI
Primary source
MGI:MGI:96200
Gene type
other
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ul; Hox-4; Hox-5; Del1Ddu; ulnaless; Del(2Hoxd1-Hoxd13)1Ddu
Annotation information
not in current annotation release
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Genomic context

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Location:
chromosome: 2

Bibliography

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Related articles in PubMed

  1. Loss of Hox5 function results in myofibroblast mislocalization and distal lung matrix defects during postnatal development. Hrycaj SM, et al. Sci China Life Sci, 2018 Sep. PMID 29752580
  2. A genetic basis for altered sexual behavior in mutant female mice. Zakany J, et al. Curr Biol, 2012 Sep 25. PMID 22863319
  3. Dissecting CTCF site function in a tense HoxD locus. Bruneau BG. Genes Dev, 2021 Nov 1. PMID 34725128, Free PMC Article
  4. The pathophysiology of HOX genes and their role in cancer. Grier DG, et al. J Pathol, 2005 Jan. PMID 15643670
  5. Hox genes in digit development and evolution. Zákány J, et al. Cell Tissue Res, 1999 Apr. PMID 10199961

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dissecting CTCF site function in a tense HoxD locus.
    Title: Dissecting CTCF site function in a tense HoxD locus.
  2. Chromatin topology and the timing of enhancer function at the HoxD locus.
    Title: Chromatin topology and the timing of enhancer function at the HoxD locus.
  3. these data indicate that Hox5 genes play a critical role in alveolar development by governing the proper cellular behavior of myofibroblasts during alveologenesis
    Title: Loss of Hox5 function results in myofibroblast mislocalization and distal lung matrix defects during postnatal development.
  4. Results reveal a novel role for Hox5 genes as developmental regulators of Th2 immune cell function that demonstrates a redeployment of mesenchyme-associated developmental genes.
    Title: Hox5 Paralogous Genes Modulate Th2 Cell Function during Chronic Allergic Inflammation via Regulation of Gata3.
  5. Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes.
    Title: Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.
  6. data show that Hox5 genes are key upstream mesenchymal regulators of the Wnt2/2b-Bmp4-signaling axis critical for proper lung patterning.
    Title: Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development.
  7. Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.
    Title: Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.
  8. HoxA and HoxD genes are required for proper AER-FGFs expression, independently of their function in controlling Shh expression
    Title: Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.
  9. one HocD duplication led to transcriptional down-regulation in developing digits by impairing physical interactions between the target genes and their upstream regulatory elements, phenocopying the effect obtained when these enhancer sequences are deleted
    Title: Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus.
  10. work uncovers a bimodal type of HoxD spatial collinearity in the developing spinal cord that relies on two separate 'enhancer mini-hubs' to ensure correct Hoxd gene expression levels while maintaining their appropriate anteroposterior boundaries
    Title: Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Other Names

  • homeo box D cluster

Gene LinkOut

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