LOC111365164 NFE2L2 motif-containing MPRA enhancers 69 and 123 [Homo sapiens (human)] - Gene

Summary

Gene symbol: LOC111365164
Gene description: NFE2L2 motif-containing MPRA enhancers 69 and 123
Gene type: biological region
Feature type(s): regulatory: enhancer, transcriptional_cis_regulatory_region
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This genomic sequence contains two overlapping regions that were predicted to be cell type-specific enhancers based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. Both regions were validated as functional enhancers by high-throughput massively parallel reporter assays (MPRAs) in liver carcinoma HepG2 cells, and one region was also active in K562 erythroleukemia cells. These overlapping enhancers contain two conserved motifs for the NFE2L2 activator. Mutation of either motif results in reduced enhancer activity. [provided by RefSeq, Nov 2017]
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Genomic context

Location:: 10q

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (77909895..77910084)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (78778942..78779131)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (79669653..79669842)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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Other Names

NFE2L2 activator MPRA enhancer 123
NFE2L2 activator MPRA enhancer 69
massively parallel reporter assay enhancers 69 and 123

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.