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LOC111365186 HNF4 motif-containing MPRA enhancer 46 [ Homo sapiens (human) ]

Gene ID: 111365186, updated on 10-Oct-2023

Summary

Gene symbol
LOC111365186
Gene description
HNF4 motif-containing MPRA enhancer 46
Gene type
biological region
Feature type(s)
regulatory: enhancer, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was predicted to be a cell type-specific enhancer based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by high-throughput massively parallel reporter assays (MPRAs) in liver carcinoma HepG2 cells. This enhancer contains a conserved motif for the HNF4 activator. Mutation of this motif results in reduced enhancer activity. [provided by RefSeq, Nov 2017]
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Genomic context

Location:
14q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (58272706..58272850)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (52479689..52479833)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (58739424..58739568)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA-Lys (anticodon CTT) 1-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8447 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:58711573-58712470 Neighboring gene proteasome 20S subunit alpha 3 Neighboring gene PSMA3 antisense RNA 1 Neighboring gene high mobility group box 1 pseudogene 14 Neighboring gene long intergenic non-protein coding RNA 216

Genomic regions, transcripts, and products

General gene information

Other Names

  • HNF4 activator MPRA enhancer 46
  • massively parallel reporter assay enhancer 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055800.1 

    Range
    101..245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    58272706..58272850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    52479689..52479833
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    GenBank, FASTA, Sequence Viewer (Graphics)