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PLAAT3 phospholipase A and acyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 11145, updated on 5-Mar-2024

Summary

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Official Symbol
PLAAT3provided by HGNC
Official Full Name
phospholipase A and acyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:17825
See related
Ensembl:ENSG00000176485 MIM:613867; AllianceGenome:HGNC:17825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AdPLA; FPLD9; HRSL3; HRASLS3; HREV107; PLA2G16; PLAAT-3; H-REV107; HREV107-1; HREV107-3; H-REV107-1
Summary
Enables N-acyltransferase activity; phospholipase A1 activity; and phospholipase A2 activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Biomarker of seminoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in fat (RPKM 173.9), testis (RPKM 32.8) and 11 other tissues See more
Orthologs
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Genomic context

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Location:
11q12.3-q13.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63574462..63616927, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63563752..63606267, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63341934..63381909, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:63312621-63313820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4871 Neighboring gene phospholipase A and acyltransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3435 Neighboring gene CRISPRi-validated cis-regulatory element chr11.2897 Neighboring gene phospholipase A and acyltransferase 2 Neighboring gene uncharacterized LOC105369335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63368875-63369376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63372619-63373384 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:63378198-63378707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63379461-63379961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3437 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:63398741-63399940 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 1 Neighboring gene atlastin GTPase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438213-63438714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438715-63439214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3441 Neighboring gene reticulon 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Screening of urine identifies PLA2G16 as a field defect methylation biomarker for prostate cancer detection. Jarrard WE, et al. PLoS One, 2019. PMID 31233548, Free PMC Article
  2. Relationship between polymorphisms of the lipid metabolism-related gene PLA2G16 and risk of colorectal cancer in the Chinese population. Xie XN, et al. Funct Integr Genomics, 2019 Mar. PMID 30343388
  3. PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway. Li L, et al. Oncotarget, 2016 Apr 5. PMID 26933804, Free PMC Article
  4. H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation. Tsai FM, et al. PLoS One, 2015. PMID 26381418, Free PMC Article
  5. PLA2G16 Expression in Human Osteosarcoma Is Associated with Pulmonary Metastasis and Poor Prognosis. Liang S, et al. PLoS One, 2015. PMID 25993412, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer.
    Title: PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer.
  2. Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.
    Title: Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.
  3. PLA2G16 methylation defines an extensive field defect in histologically normal prostate tissue associated with PC.
    Title: Screening of urine identifies PLA2G16 as a field defect methylation biomarker for prostate cancer detection.
  4. PLA2G16 SNPs are associated with the colorectal cancer risk in the Chinese population.
    Title: Relationship between polymorphisms of the lipid metabolism-related gene PLA2G16 and risk of colorectal cancer in the Chinese population.
  5. study uncovers two competing processes triggered by Picornaviridae virus entry: activation of a pore-activated clearance pathway and recruitment of a PLA2G16 phospholipase to enable genome release
    Title: PLA2G16 represents a switch between entry and clearance of Picornaviridae.
  6. Demonstrate increased PLA2G16 expression activates the MAPK pathway to enhance osteosarcoma metastasis.
    Title: PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway.
  7. our results revealed that H-rev107 is also involved in lipid accumulation in liver cells through the POR pathway via its PLA2 activity.
    Title: H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation.
  8. Results show that osteosarcoma patients with metastasis showed higher expression of PLA2G16 at both the mRNA and protein levels and shorter overall survival suggesting it as significant prognostic factor for poor outcome.
    Title: PLA2G16 Expression in Human Osteosarcoma Is Associated with Pulmonary Metastasis and Poor Prognosis.
  9. suggest a novel regulatory mechanism for peroxisome biogenesis through the interaction between Pex19p and PLA/AT-3
    Title: Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.
  10. the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.
    Title: Structural and functional characterization of tumor suppressors TIG3 and H-REV107.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Lipodystrophy, familial partial, type 9
MedGen: CN376198 OMIM: 620683 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118754

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyltransferase activity TAS
Traceable Author Statement
more info
  
enables lipid binding EXP
Inferred from Experiment
more info
 PubMed 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ether lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in localization EXP
Inferred from Experiment
more info
 PubMed 
involved_in membrane disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in organelle disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peroxisome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of adipose tissue development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase A and acyltransferase 3
Names
Ca-independent phospholipase A1/2
H-rev 107 protein homolog
HRAS-like suppressor 1
HRAS-like suppressor 3
adipose-specific PLA2
adipose-specific phospholipase A2
group XVI phospholipase A1/A2
group XVI phospholipase A2
phospholipase A/acyltransferase-3
phospholipase A2 group XVI
renal carcinoma antigen NY-REN-65
NP_001121675.1
NP_009000.2
XP_011543043.1
XP_054223515.1
XP_054223516.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128203.2 → NP_001121675.1  phospholipase A and acyltransferase 3

    See identical proteins and their annotated locations for NP_001121675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI374456, AI590735, BG719903, CK003948
    Consensus CDS
    CCDS8047.1
    UniProtKB/Swiss-Prot
    B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1
    Related
    ENSP00000389124.1, ENST00000415826.3
    Conserved Domains (1) summary
    pfam04970
    Location:19 → 125
    LRAT; Lecithin retinol acyltransferase

  2. NM_007069.3 → NP_009000.2  phospholipase A and acyltransferase 3

    See identical proteins and their annotated locations for NP_009000.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI374456, AI590735, AK313075, AU099540
    Consensus CDS
    CCDS8047.1
    UniProtKB/Swiss-Prot
    B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1
    Related
    ENSP00000320337.5, ENST00000323646.9
    Conserved Domains (1) summary
    pfam04970
    Location:19 → 125
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63574462..63616927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544741.2 → XP_011543043.1  phospholipase A and acyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011543043.1

    Conserved Domains (1) summary
    pfam04970
    Location:35 → 140
    LRAT; Lecithin retinol acyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63563752..63606267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367540.1 → XP_054223515.1  phospholipase A and acyltransferase 3 isoform X1

  2. XM_054367541.1 → XP_054223516.1  phospholipase A and acyltransferase 3 isoform X2

    UniProtKB/Swiss-Prot
    B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53816.2 GenPept UniProtKB/Swiss-Prot:P53816

Gene LinkOut

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