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MRPL3 mitochondrial ribosomal protein L3 [ Homo sapiens (human) ]

Gene ID: 11222, updated on 27-Nov-2024

Summary

Official Symbol
MRPL3provided by HGNC
Official Full Name
mitochondrial ribosomal protein L3provided by HGNC
Primary source
HGNC:HGNC:10379
See related
Ensembl:ENSG00000114686 MIM:607118; AllianceGenome:HGNC:10379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRL3; uL3m; RPML3; COXPD9
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 34.3), colon (RPKM 33.4) and 25 other tissues See more
Orthologs
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Genomic context

See MRPL3 in Genome Data Viewer
Location:
3q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (131462212..131502971, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (134205979..134246719, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (131181056..131221815, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986025 Neighboring gene uncharacterized LOC105374110 Neighboring gene uncharacterized LOC105374114 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131221451-131222137 Neighboring gene small nucleolar RNA, H/ACA box 58 Neighboring gene BCL2 like 12 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14738 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:131287110-131287684 Neighboring gene copine 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20534 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:131515358-131515894 Neighboring gene uncharacterized LOC105374113 Neighboring gene Sharpr-MPRA regulatory region 7150

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
large ribosomal subunit protein uL3m
Names
39S ribosomal protein L3, mitochondrial
L3mt
MRP-L3
mitochondrial 60S ribosomal protein L3
mitochondrial large ribosomal subunit protein uL3m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029207.1 RefSeqGene

    Range
    5046..45805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007208.4NP_009139.1  large ribosomal subunit protein uL3m

    See identical proteins and their annotated locations for NP_009139.1

    Status: REVIEWED

    Source sequence(s)
    BC003375, DC398662, X06323
    Consensus CDS
    CCDS3071.1
    UniProtKB/Swiss-Prot
    P09001, Q6IBT2
    UniProtKB/TrEMBL
    E7ETU7
    Related
    ENSP00000264995.2, ENST00000264995.8
    Conserved Domains (1) summary
    pfam00297
    Location:3340
    Ribosomal_L3; Ribosomal protein L3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    131462212..131502971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    134205979..134246719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)