U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC112296175 Sharpr-MPRA regulatory region 12031 [ Homo sapiens (human) ]

Gene ID: 112296175, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC112296175
Gene description
Sharpr-MPRA regulatory region 12031
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in both HepG2 liver carcinoma cells (group: HepG2 Activating non-DNase unmatched - State 22:ReprW, weaker Polycomb repression) and K562 erythroleukemia cells (group: K562 Activating DNase matched - State 4:PromP, inactive/poised promoter, highly conserved). [provided by RefSeq, Apr 2018]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (91291719..91292013)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (89052497..89052791)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91834949..91835243)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91586547-91587048 Neighboring gene golgin A2 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:91642723-91643264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91653317-91653843 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91653844-91654369 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:91656268-91656428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10109 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:91698560-91699759 Neighboring gene synaptic vesicle glycoprotein 2B Neighboring gene uncharacterized LOC105370972 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:91885743-91886942 Neighboring gene uncharacterized LOC107984778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10110 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:92042895-92043798 Neighboring gene cervical cancer-associated transcript 37 Neighboring gene Sharpr-MPRA regulatory region 1362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:92170550-92171050 Neighboring gene uncharacterized LOC105370973

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_056760.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    91291719..91292013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    89052497..89052791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases