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SPADH spermadhesin family member [ Homo sapiens (human) ]

Gene ID: 112577516, updated on 15-Mar-2024

Summary

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Official Symbol
SPADHprovided by HGNC
Official Full Name
spermadhesin family memberprovided by HGNC
Primary source
HGNC:HGNC:55808
See related
Ensembl:ENSG00000286135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
all
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Genomic context

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See SPADH in Genome Data Viewer
Location:
10q26.13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (122672850..122679494)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (123547893..123554537)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124432366..124439010)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124233495-124234018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124234019-124234540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124235637-124236362 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:124253973-124255172 Neighboring gene HtrA serine peptidase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124264199-124264698 Neighboring gene deleted in malignant brain tumors 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:124398858-124400057 Neighboring gene Sharpr-MPRA regulatory region 5374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124424211-124424711 Neighboring gene chromosome 10 open reading frame 120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124527221-124527722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124527723-124528222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124539143-124539651 Neighboring gene deleted in malignant brain tumors 1 like 1 (pseudogene) Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:124556394-124557593

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CHESS: a new human gene catalog curated from thousands of large-scale RNA sequencing experiments reveals extensive transcriptional noise. Pertea M, et al. Genome Biol, 2018 Nov 28. PMID 30486838, Free PMC Article
  2. Evolution of the spermadhesin gene family. Haase B, et al. Gene, 2005 Jun 6. PMID 15922517

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

General protein information

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Preferred Names
CUB domain-containing protein
Names
carbohydrate-binding protein AQN-1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364461.3 → NP_001351390.1  CUB domain-containing protein precursor

    Status: VALIDATED

    Source sequence(s)
    AL603764
    Consensus CDS
    CCDS91369.1
    UniProtKB/Swiss-Prot
    A0A494C103
    Related
    ENSP00000498797.1, ENST00000652090.1
    Conserved Domains (1) summary
    cl00049
    Location:30 → 129
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    122672850..122679494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    123547893..123554537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A494C103.1 GenPept UniProtKB/Swiss-Prot:A0A494C103

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials