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Slc6a20a solute carrier family 6 member 20a [ Rattus norvegicus (Norway rat) ]

Gene ID: 113918, updated on 10-Jul-2024

Summary

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Official Symbol
Slc6a20aprovided by RGD
Official Full Name
solute carrier family 6 member 20aprovided by RGD
Primary source
RGD:621651
See related
EnsemblRapid:ENSRNOG00000068642 AllianceGenome:RGD:621651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Xtrp3; rB21a; Slc6a20
Summary
Enables L-proline transmembrane transporter activity; amino-acid betaine transmembrane transporter activity; and proline:sodium symporter activity. Involved in L-proline import across plasma membrane and amino-acid betaine transport. Predicted to be located in apical plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to human SLC6A20 (solute carrier family 6 member 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 153.5), Brain (RPKM 114.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc6a20a in Genome Data Viewer
Location:
8q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (132159768..132200016, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (123282325..123322609, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (132713013..132753145, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480118 Neighboring gene transfer RNA arginine (anticodon ACG) 2 Neighboring gene SAC1 like phosphatidylinositide phosphatase Neighboring gene solute carrier family 6 member 20b Neighboring gene leucine zipper transcription factor-like 1 Neighboring gene ribosomal biogenesis factor, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Na+-dependent and Na+-independent betaine transport across the apical membrane of rat renal epithelium. Cano M, et al. Biochim Biophys Acta, 2015 Oct. PMID 26028423
  2. Molecular cloning of an orphan transporter. A new member of the neurotransmitter transporter family. Smith KE, et al. FEBS Lett, 1995 Jan 2. PMID 8001687
  3. Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter. Kowalczuk S, et al. Biochem J, 2005 Mar 15. PMID 15689184, Free PMC Article
  4. Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. Bröer S, et al. J Clin Invest, 2008 Dec. PMID 19033659, Free PMC Article
  5. SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage. Anas MK, et al. Development, 2008 Dec. PMID 19029042

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-proline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-proline transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-proline transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables L-proline transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino-acid betaine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables neutral L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proline:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables proline:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables proline:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proline:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables solute:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables solute:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-proline import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-proline import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-proline import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in L-proline import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in amino-acid betaine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino-acid betaine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycine import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in proline import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in proline transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium- and chloride-dependent transporter XTRP3
Names
X transporter protein 3
sodium/imino-acid transporter 1
solute carrier family 6 (neurotransmitter transporter), member 20
solute carrier family 6 (proline IMINO transporter), member 20
solute carrier family 6 member 20
transporter rB21A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133296.2 → NP_579830.2  sodium- and chloride-dependent transporter XTRP3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q64093
    UniProtKB/TrEMBL
    A6I4C2, G3V6Q4
    Related
    ENSRNOP00000007467.4, ENSRNOT00000007467.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    132159768..132200016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264728.1 → XP_063120798.1  sodium- and chloride-dependent transporter XTRP3 isoform X3

  2. XM_039080653.2 → XP_038936581.1  sodium- and chloride-dependent transporter XTRP3 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:26 → 336
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_063264726.1 → XP_063120796.1  sodium- and chloride-dependent transporter XTRP3 isoform X2

  4. XM_063264729.1 → XP_063120799.1  sodium- and chloride-dependent transporter XTRP3 isoform X3

  5. XM_063264725.1 → XP_063120795.1  sodium- and chloride-dependent transporter XTRP3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64093.1 GenPept UniProtKB/Swiss-Prot:Q64093

Gene LinkOut

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