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Gmfg glia maturation factor, gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 113940, updated on 2-Nov-2024

Summary

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Official Symbol
Gmfgprovided by RGD
Official Full Name
glia maturation factor, gammaprovided by RGD
Primary source
RGD:620506
See related
EnsemblRapid:ENSRNOG00000019838 AllianceGenome:RGD:620506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable Arp2/3 complex binding activity. Predicted to be involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be active in cortical actin cytoskeleton. Orthologous to human GMFG (glia maturation factor gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 1010.3), Spleen (RPKM 387.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gmfg in Genome Data Viewer
Location:
1q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (92856154..92866722)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83728797..83739189)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85312473..85322860, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene sterile alpha motif domain containing 4B Neighboring gene leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene interferon, lambda 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of a rat glia maturation factor-gamma (rGMFG) cDNA and expression of its mRNA and protein in rat organs. Tsuiki H, et al. J Biochem, 2000 Mar. PMID 10731725
  2. GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism. Ydenberg CA, et al. Curr Biol, 2013 Jun 17. PMID 23727094, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Arp2/3 complex binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament debranching IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament debranching IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actin filament debranching ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glia maturation factor gamma
Names
GMF-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429255.1 → NP_001416184.1  glia maturation factor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6J9J2

  2. NM_001429256.1 → NP_001416185.1  glia maturation factor gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6GI11

  3. NM_001429257.1 → NP_001416186.1  glia maturation factor gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  4. NM_001429258.1 → NP_001416187.1  glia maturation factor gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AD83, A6J9J4

  5. NM_001429259.1 → NP_001416188.1  glia maturation factor gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AD83, A6J9J4

  6. NM_181091.3 → NP_851605.2  glia maturation factor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6J9J2
    Related
    ENSRNOP00000026891.6, ENSRNOT00000026891.8

RNA

  1. NR_190702.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    92856154..92866722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288517.1 → XP_063144587.1  glia maturation factor gamma isoform X1

  2. XM_006228606.5 → XP_006228668.3  glia maturation factor gamma isoform X2

    Related
    ENSRNOP00000089766.2, ENSRNOT00000118600.2

  3. XM_063288636.1 → XP_063144706.1  glia maturation factor gamma isoform X6

  4. XM_063288563.1 → XP_063144633.1  glia maturation factor gamma isoform X3

  5. XM_063288623.1 → XP_063144693.1  glia maturation factor gamma isoform X6

  6. XM_039105677.2 → XP_038961605.1  glia maturation factor gamma isoform X4

    Related
    ENSRNOP00000089358.1, ENSRNOT00000118560.2
    Conserved Domains (1) summary
    cd11283
    Location:10 → 131
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

  7. XM_063288604.1 → XP_063144674.1  glia maturation factor gamma isoform X5

RNA

  1. XR_010066526.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80T18.1 GenPept UniProtKB/Swiss-Prot:Q80T18

Gene LinkOut

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