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Maged2 MAGE family member D2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 113947, updated on 2-Nov-2024

Summary

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Official Symbol
Maged2provided by RGD
Official Full Name
MAGE family member D2provided by RGD
Primary source
RGD:70899
See related
EnsemblRapid:ENSRNOG00000002449 AllianceGenome:RGD:70899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in female pregnancy; negative regulation of transcription by RNA polymerase II; and renal sodium ion absorption. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Bartter disease type 5. Orthologous to human MAGED2 (MAGE family member D2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 811.2), Muscle (RPKM 214.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Maged2 in Genome Data Viewer
Location:
Xq12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (23160928..23364994, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (19733593..19741769, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (33174539..33182715, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance complex component 2, pseudogene 1 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene ras homolog family member A, pseudogene 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene oligosaccharyltransferase complex non-catalytic subunit, pseudogene 1 Neighboring gene aminoacylase 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues. Langnaese K, et al. Cytogenet Cell Genet, 2001. PMID 11856887
  2. Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations. Laghmani K, et al. N Engl J Med, 2016 May 12. PMID 27120771
  3. Mammalian small nucleolar RNAs are mobile genetic elements. Weber MJ. PLoS Genet, 2006 Dec 8. PMID 17154719, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues
    Title: Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC124946

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in female pregnancy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanoma-associated antigen D2
Names
melanoma antigen, family D, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271109.1 → NP_001258038.1  melanoma-associated antigen D2

    See identical proteins and their annotated locations for NP_001258038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC107467
    UniProtKB/TrEMBL
    A0A0G2K8U1, Q3B7U1, Q9EPI7
    Conserved Domains (2) summary
    pfam01454
    Location:286 → 454
    MAGE; MAGE family
    NF033761
    Location:32 → 171
    gliding_GltJ; adventurous gliding motility protein GltJ

  2. NM_001271110.1 → NP_001258039.1  melanoma-associated antigen D2

    See identical proteins and their annotated locations for NP_001258039.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC107467, FM059132
    UniProtKB/TrEMBL
    A0A0G2K8U1, Q3B7U1, Q9EPI7
    Conserved Domains (2) summary
    pfam01454
    Location:286 → 454
    MAGE; MAGE family
    NF033761
    Location:32 → 171
    gliding_GltJ; adventurous gliding motility protein GltJ

  3. NM_080479.2 → NP_536727.2  melanoma-associated antigen D2

    See identical proteins and their annotated locations for NP_536727.2

    Status: VALIDATED

    Source sequence(s)
    BC107467
    UniProtKB/TrEMBL
    A0A0G2K8U1, Q3B7U1, Q9EPI7
    Related
    ENSRNOP00000074736.1, ENSRNOT00000080358.3
    Conserved Domains (2) summary
    pfam01454
    Location:286 → 454
    MAGE; MAGE family
    NF033761
    Location:32 → 171
    gliding_GltJ; adventurous gliding motility protein GltJ

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    23160928..23364994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279730.1 → XP_063135800.1  melanoma-associated antigen D2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8U1, Q3B7U1

  2. XM_063279729.1 → XP_063135799.1  melanoma-associated antigen D2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8U1, Q3B7U1

  3. XM_017593115.3 → XP_017448604.1  melanoma-associated antigen D2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8U1, Q3B7U1, Q9EPI7
    Conserved Domains (2) summary
    pfam01454
    Location:286 → 454
    MAGE; MAGE family
    NF033761
    Location:32 → 171
    gliding_GltJ; adventurous gliding motility protein GltJ

  4. XM_006237924.5 → XP_006237986.1  melanoma-associated antigen D2 isoform X1

    See identical proteins and their annotated locations for XP_006237986.1

    UniProtKB/TrEMBL
    A0A0G2K8U1, Q3B7U1, Q9EPI7
    Conserved Domains (2) summary
    pfam01454
    Location:286 → 454
    MAGE; MAGE family
    NF033761
    Location:32 → 171
    gliding_GltJ; adventurous gliding motility protein GltJ

  5. XM_063279731.1 → XP_063135801.1  melanoma-associated antigen D2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8U1, Q3B7U1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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