Pom121 POM121 transmembrane nucleoporin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pom121provided by RGD
Official Full Name: POM121 transmembrane nucleoporinprovided by RGD
Primary source: RGD:620680
See related: EnsemblRapid:ENSRNOG00000001449 AllianceGenome:RGD:620680
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: A structural constituent of nuclear pore. Involved in nuclear pore organization. Part of nuclear pore. Orthologous to several human genes including POM121 (POM121 transmembrane nucleoporin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 41.4), Thymus (RPKM 38.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (26913513..26930861)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (21273713..21294299)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (24316575..24341943)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The propose a model in which POM121 and Sun1 interact transiently to promote early steps of interphase nuclear pore complexes assembly.
Title: POM121 and Sun1 play a role in early steps of interphase NPC assembly.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore organization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear envelope pore membrane protein POM 121

Names: P145; POM121 membrane glycoprotein; integral membrane glycoprotein; nuclear pore membrane glycoprotein 121 kD; nuclear pore membrane protein 121; nucleoporin Nup121; pore membrane protein of 121 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053622.2 → NP_446074.2 nuclear envelope pore membrane protein POM 121

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P52591

UniProtKB/TrEMBL

A6J0D1, G3V659

Related

ENSRNOP00000001968.1, ENSRNOT00000001968.4

Conserved Domains (3) summary

PHA03247
Location:422 → 761

PHA03247; large tegument protein UL36; Provisional

pfam15229
Location:292 → 527

POM121; POM121 family

pfam15967
Location:911 → 1021

Nucleoporin_FG2; Nucleoporin FG repeated region