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Glrx2 glutaredoxin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114022, updated on 17-Aug-2024

Summary

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Official Symbol
Glrx2provided by RGD
Official Full Name
glutaredoxin 2provided by RGD
Primary source
RGD:1307950
See related
EnsemblRapid:ENSRNOG00000003385 AllianceGenome:RGD:1307950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-disulfide reductase activity. Involved in aging and cellular response to superoxide. Located in several cellular components, including dendrite; mitochondrial matrix; and neuronal cell body. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 144.7), Brain (RPKM 127.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Glrx2 in Genome Data Viewer
Location:
13q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (58032199..58055061)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (55481875..55504737)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (60529057..60552115)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 73 Neighboring gene Beta-1,3-galactosyltransferase 2 Neighboring gene uncharacterized LOC108352545 Neighboring gene Ro60, Y RNA binding protein Neighboring gene uncharacterized LOC120096268 Neighboring gene small Cajal body-specific RNA 18B Neighboring gene ubiquitin C-terminal hydrolase L5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Aging-dependent changes in rat heart mitochondrial glutaredoxins--Implications for redox regulation. Gao XH, et al. Redox Biol, 2013. PMID 25126518, Free PMC Article
  2. Identification of potential protein dithiol-disulfide substrates of mammalian Grx2. Schütte LD, et al. Biochim Biophys Acta, 2013 Nov. PMID 23872354
  3. What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria? Pai HV, et al. Antioxid Redox Signal, 2007 Nov. PMID 17845131
  4. Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. Gladyshev VN, et al. J Biol Chem, 2001 Aug 10. PMID 11397793
  5. Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia. Romero JI, et al. Biochim Biophys Acta, 2015 Jun. PMID 25735211

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Grx2 and Trx1 contribute significantly to neuronal integrity and could be clinically relevant in neuronal damage following perinatal asphyxia and other neuronal disorders.
    Title: Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia.
  2. Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.
    Title: Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to superoxide IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutaredoxin-2, mitochondrial
Names
glutaredoxin 2 (thioltransferase)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394170.1 → NP_001381099.1  glutaredoxin-2, mitochondrial 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q6AXW1
    UniProtKB/TrEMBL
    A6ICN9
    Conserved Domains (1) summary
    cd03419
    Location:61 → 142
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  2. NM_001394171.1 → NP_001381100.1  glutaredoxin-2, mitochondrial 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICP1
    Conserved Domains (1) summary
    cd03419
    Location:28 → 109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  3. NM_001394172.1 → NP_001381101.1  glutaredoxin-2, mitochondrial 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICP1
    Conserved Domains (1) summary
    cd03419
    Location:28 → 109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

RNA

  1. NR_172084.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    58032199..58055061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271953.1 → XP_063128023.1  glutaredoxin-2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6AXW1
    UniProtKB/TrEMBL
    A6ICN9

  2. XM_006249955.4 → XP_006250017.1  glutaredoxin-2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006250017.1

    UniProtKB/Swiss-Prot
    Q6AXW1
    UniProtKB/TrEMBL
    A6ICN9
    Related
    ENSRNOP00000056811.2, ENSRNOT00000060062.6
    Conserved Domains (1) summary
    cd03419
    Location:61 → 142
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  3. XM_039090231.2 → XP_038946159.1  glutaredoxin-2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6ICP1
    Conserved Domains (1) summary
    cd03419
    Location:28 → 109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  4. XM_008769526.4 → XP_008767748.1  glutaredoxin-2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_008767748.1

    UniProtKB/TrEMBL
    A6ICP1
    Conserved Domains (1) summary
    cd03419
    Location:28 → 109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  5. XM_039090229.2 → XP_038946157.1  glutaredoxin-2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6ICP1
    Related
    ENSRNOP00000096477.1, ENSRNOT00000106322.2
    Conserved Domains (1) summary
    cd03419
    Location:28 → 109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  6. XM_063271954.1 → XP_063128024.1  glutaredoxin-2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6ICP1

RNA

  1. XR_001840761.3 RNA Sequence

  2. XR_010056897.1 RNA Sequence

  3. XR_010056898.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXW1.2 GenPept UniProtKB/Swiss-Prot:Q6AXW1

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