Fstl3 follistatin like 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fstl3provided by RGD
Official Full Name: follistatin like 3provided by RGD
Primary source: RGD:621811
See related: EnsemblRapid:ENSRNOG00000009311 AllianceGenome:RGD:621811
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Flrg
Summary: Predicted to enable activin binding activity and fibronectin binding activity. Involved in several processes, including adrenal gland development; male gonad development; and spermatogenesis. Located in extracellular space; neuron projection terminus; and secretory granule. Orthologous to human FSTL3 (follistatin like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 43.0), Testes (RPKM 34.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10574195..10579844, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9923574..9929223, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12806031..12810556, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients.
Title: The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients.
FSTL3 is a critical mediator of exercise-dependent bone formation
Title: Follistatin-like 3 is a mediator of exercise-driven bone formation and strengthening.
Suggest FSTL3 has a role in paracrine communication between cardiomyocytes and fibroblasts.
Title: Follistatin-like 3 mediates paracrine fibroblast activation by cardiomyocytes.
Fstl3 as a stress-induced regulator of hypertrophy that controls myocyte size via regulation of Smad signaling.
Title: Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy.
maternal undernutrition during gestation results in the aberrant regulation of myostatin and follistatin-like-3 in the placenta and skeletal muscle
Title: Placental expression of myostatin and follistatin-like-3 protein in a model of developmental programming.
Activin betaA subunit, follistatin and follistatin-like 3 are expressed in the endometrium of ovariectomized rats and regulated by estrogen replacement
Title: Activin betaA subunit, follistatin and follistatin-like 3 are expressed in the endometrium of ovariectomized rats and regulated by estrogen replacement.
FLRG protein may be involved in the maintenance of spermatogenesis in the testis and the growth and function of adrenal tissue cells
Title: Purification, cDNA cloning, and secretory properties of FLRG protein from PC12 cells and the distribution of FLRG mRNA and protein in rat tissues.
Follistatin-like 3 expression was low in normal but enhanced in malignant rat liver. in human normal liver, in contrast, it was abundantly expressed but downregulated in liver cancer
Title: Deregulation of the activin/follistatin system in hepatocarcinogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

BE099290 (e-PCR)
- UniSTS:245637

RH139332 (e-PCR)
- UniSTS:221418

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin binding	IEA Inferred from Electronic Annotation more info
enables activin binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: follistatin-related protein 3

Names: follistatin-like 3 (secreted glycoprotein); follistatin-like protein 3; follistatin-related gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053629.4 → NP_446081.1 follistatin-related protein 3 precursor

See identical proteins and their annotated locations for NP_446081.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q54A93, Q99PW7

UniProtKB/TrEMBL

A6K8X5

Related

ENSRNOP00000012578.4, ENSRNOT00000012578.7

Conserved Domains (2) summary

smart00280
Location:118 → 165

KAZAL; Kazal type serine protease inhibitors

cd00104
Location:198 → 241

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...