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Kremen1 kringle containing transmembrane protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114107, updated on 10-Oct-2024

Summary

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Official Symbol
Kremen1provided by RGD
Official Full Name
kringle containing transmembrane protein 1provided by RGD
Primary source
RGD:620789
See related
EnsemblRapid:ENSRNOG00000051487 AllianceGenome:RGD:620789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kremen
Summary
Predicted to be involved in several processes, including negative regulation of axon regeneration; negative regulation of canonical Wnt signaling pathway; and negative regulation of ossification. Predicted to be located in neuronal cell body. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 13. Orthologous to human KREMEN1 (kringle containing transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 92.1), Heart (RPKM 58.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kremen1 in Genome Data Viewer
Location:
14q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84295931..84361534, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80081870..80147489, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85441209..85503661, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1 Neighboring gene chromosome 14 C22orf31 homolog Neighboring gene zinc and ring finger 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist Kremen1. Wu D, et al. Front Mol Neurosci, 2013. PMID 24167472, Free PMC Article
  2. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Nakamura T, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267660
  3. Function and biological roles of the Dickkopf family of Wnt modulators. Niehrs C. Oncogene, 2006 Dec 4. PMID 17143291
  4. Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner. Causeret F, et al. Cell Death Differ, 2016 Feb. PMID 26206087, Free PMC Article
  5. Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Ellwanger K, et al. Mol Cell Biol, 2008 Aug. PMID 18505822, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in limb development IEA
Inferred from Electronic Annotation
more info
  
involved_in limb development ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle organ development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of axon regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kremen protein 1
Names
dickkopf receptor
kringle domain-containing transmembrane protein 1
kringle-coding gene marking the eye and the nose
kringle-containing protein marking the eye and the nose
XP_038947484.1
XP_063128872.1
XP_063128873.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433772.1 → NP_001420701.1  kremen protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  2. NM_053649.2 → NP_446101.2  kremen protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000085129.1, ENSRNOT00000120167.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84295931..84361534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091556.2 → XP_038947484.1  kremen protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G4R3
    Conserved Domains (3) summary
    cd00041
    Location:214 → 320
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00108
    Location:29 → 114
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    pfam01822
    Location:120 → 200
    WSC; WSC domain

  2. XM_063272802.1 → XP_063128872.1  kremen protein 1 isoform X2

  3. XM_063272803.1 → XP_063128873.1  kremen protein 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924S4.1 GenPept UniProtKB/Swiss-Prot:Q924S4

Gene LinkOut

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