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Akap1 A-kinase anchoring protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114124, updated on 2-Nov-2024

Summary

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Official Symbol
Akap1provided by RGD
Official Full Name
A-kinase anchoring protein 1provided by RGD
Primary source
RGD:620826
See related
EnsemblRapid:ENSRNOG00000002373 AllianceGenome:RGD:620826
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akap84
Summary
Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and tubulin binding activity. Involved in several processes, including cellular response to cAMP; negative regulation of cell growth involved in cardiac muscle cell development; and negative regulation of protein import into nucleus. Located in lipid droplet; mitochondrial crista; and postsynaptic membrane. Is active in neuromuscular junction and postsynaptic specialization, intracellular component. Biomarker of brain ischemia. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 364.2), Testes (RPKM 254.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Akap1 in Genome Data Viewer
Location:
10q26
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (74118232..74151366, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (73621021..73654123, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (76151013..76183987, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene musashi RNA-binding protein 2 Neighboring gene uncharacterized LOC134480853 Neighboring gene uncharacterized LOC134480854 Neighboring gene uncharacterized LOC134480855 Neighboring gene U6 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit A13, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells. Feliciello A, et al. J Biol Chem, 1998 Sep 4. PMID 9722570
  2. Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein. Bridges D, et al. Biochem Biophys Res Commun, 2006 Jul 21. PMID 16756943
  3. The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy. Abrenica B, et al. J Mol Cell Cardiol, 2009 May. PMID 19358331
  4. AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes. Chen Z, et al. J Cell Physiol, 2020 Oct. PMID 32108342
  5. Organelle-specific targeting of protein kinase AII (PKAII). Molecular and in situ characterization of murine A kinase anchor proteins that recruit regulatory subunits of PKAII to the cytoplasmic surface of mitochondria. Chen Q, et al. J Biol Chem, 1997 Jun 13. PMID 9182549

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission.
    Title: AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission.
  2. AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes.
    Title: AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes.
  3. the scaffold protein A kinase anchoring protein 1 brings the cAMP-dependent protein kinase A to the outer mitochondrial membrane to protect neurons from injury
    Title: Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1.
  4. AKAP121 regulates the response to stress in cardiomyocytes, and therefore AKAP121 downregulation might represent an important event contributing to the development of cardiac dysfunction.
    Title: AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress.
  5. We purified a 120 kDa protein which can bind both the regulatory subunit of PKA as well as the catalytic subunit of protein phosphatase 1 (PP1)
    Title: Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein.
  6. These results are the first to identify AKAP121 as a negative regulator of cardiomyocyte hypertrophy.
    Title: The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy.
  7. 90% or more of mitochondrial C-PKA, R-PKA and AKAP121 is localized in the inner mitochondrial compartment, when prepared both from isolated mitochondria or cardiomyocyte cultures
    Title: Occurrence of A-kinase anchor protein and associated cAMP-dependent protein kinase in the inner compartment of mammalian mitochondria.
  8. Akap1 signaling complex mediates Adra1a-induced cardiomyocyte hypertrophy.
    Title: The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A regulatory subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in antiviral innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to peptide hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase A signaling IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial crista IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
A-kinase anchor protein 1, mitochondrial
Names
A kinase (PRKA) anchor protein 1
A-kinase anchor protein 121 kDa
AKAP 121
D-AKAP-1
PRKA1
S-AKAP84
a kinase anchor protein 1, mitochondrial
dual specificity A-kinase-anchoring protein 1
protein kinase A-anchoring protein 1
spermatid A-kinase anchor protein 84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053665.1 → NP_446117.1  A-kinase anchor protein 1, mitochondrial

    See identical proteins and their annotated locations for NP_446117.1

    Status: PROVISIONAL

    Source sequence(s)
    AF068202
    UniProtKB/Swiss-Prot
    O88884, O88980
    Conserved Domains (4) summary
    smart00333
    Location:707 → 765
    TUDOR; Tudor domain
    cd00105
    Location:562 → 622
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:655 → 777
    TUDOR; Tudor domain
    pfam04814
    Location:394 → 510
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    74118232..74151366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247068.3 → XP_006247130.1  A-kinase anchor protein 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006247130.1

    UniProtKB/TrEMBL
    A6HHY7, F1LMK0
    Conserved Domains (4) summary
    smart00333
    Location:707 → 765
    TUDOR; Tudor domain
    cd00105
    Location:562 → 622
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:655 → 777
    TUDOR; Tudor domain
    pfam04814
    Location:394 → 510
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  2. XM_063268270.1 → XP_063124340.1  A-kinase anchor protein 1, mitochondrial isoform X4

  3. XM_006247067.5 → XP_006247129.1  A-kinase anchor protein 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006247129.1

    UniProtKB/TrEMBL
    A6HHY7, F1LMK0
    Conserved Domains (4) summary
    smart00333
    Location:707 → 765
    TUDOR; Tudor domain
    cd00105
    Location:562 → 622
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:655 → 777
    TUDOR; Tudor domain
    pfam04814
    Location:394 → 510
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  4. XM_063268268.1 → XP_063124338.1  A-kinase anchor protein 1, mitochondrial isoform X4

  5. XM_008767930.3 → XP_008766152.1  A-kinase anchor protein 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_008766152.1

    UniProtKB/TrEMBL
    A6HHY7, F1LMK0
    Related
    ENSRNOP00000052543.5, ENSRNOT00000055683.7
    Conserved Domains (4) summary
    smart00333
    Location:707 → 765
    TUDOR; Tudor domain
    cd00105
    Location:562 → 622
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:655 → 777
    TUDOR; Tudor domain
    pfam04814
    Location:394 → 510
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  6. XM_063268271.1 → XP_063124341.1  A-kinase anchor protein 1, mitochondrial isoform X5

  7. XM_063268272.1 → XP_063124342.1  A-kinase anchor protein 1, mitochondrial isoform X5

  8. XM_039085023.2 → XP_038940951.1  A-kinase anchor protein 1, mitochondrial isoform X2

    Conserved Domains (2) summary
    PHA03307
    Location:336 → 498
    PHA03307; transcriptional regulator ICP4; Provisional
    cd22395
    Location:560 → 609
    KH-I_AKAP1; type I K homology (KH) RNA-binding domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins

  9. XM_039085025.2 → XP_038940953.1  A-kinase anchor protein 1, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6HHY9, D4A9M6
    Related
    ENSRNOP00000003251.7, ENSRNOT00000003251.9
    Conserved Domains (1) summary
    NF033201
    Location:279 → 490
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip

RNA

  1. XR_005489677.2 RNA Sequence

  2. XR_005489675.2 RNA Sequence

  3. XR_005489674.2 RNA Sequence

  4. XR_005489676.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88884.1 GenPept UniProtKB/Swiss-Prot:O88884

Gene LinkOut

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