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Slfn4 schlafen family member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114247, updated on 2-Nov-2024

Summary

Official Symbol
Slfn4provided by RGD
Official Full Name
schlafen family member 4provided by RGD
Primary source
RGD:620455
See related
AllianceGenome:RGD:620455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Slfn3; Cdk107
Summary
Predicted to enable RNA nuclease activity and ribosome binding activity. Involved in lung alveolus development. Predicted to be located in cytosol and nucleus. Orthologous to several human genes including SLFN12 (schlafen family member 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 462.2), Lung (RPKM 285.9) and 7 other tissues See more
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Genomic context

See Slfn4 in Genome Data Viewer
Location:
10q26
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68492135..68515674)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67994601..68018141)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70411686..70435162)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene schlafen family member 2 Neighboring gene schlafen family member 1 Neighboring gene glutathione S-transferase, alpha 4 like 1 Neighboring gene schlafen family member 3 Neighboring gene schlafen family member 4 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in lung alveolus development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in rRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
schlafen family member 4
Names
schlafen 3
schlafen 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430210.1NP_001417139.1  schlafen family member 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K750, Q9TPX1
  2. NM_053687.2NP_446139.1  schlafen family member 4

    See identical proteins and their annotated locations for NP_446139.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K4S0, A0A0G2K750, Q9TPX1
    Conserved Domains (1) summary
    PHA02782
    Location:47329
    PHA02782; hypothetical protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    68492135..68515674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767933.4XP_008766155.1  schlafen family member 4 isoform X1

    Conserved Domains (1) summary
    PHA02782
    Location:47329
    PHA02782; hypothetical protein; Provisional
  2. XM_039085031.2XP_038940959.1  schlafen family member 4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4S0, A0A0G2K750, Q9TPX1
    Conserved Domains (1) summary
    PHA02782
    Location:47329
    PHA02782; hypothetical protein; Provisional
  3. XM_017596949.3XP_017452438.1  schlafen family member 4 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4S0