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Pde6h phosphodiesterase 6H [ Rattus norvegicus (Norway rat) ]

Gene ID: 114248, updated on 3-Apr-2024

Summary

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Official Symbol
Pde6hprovided by RGD
Official Full Name
phosphodiesterase 6Hprovided by RGD
Primary source
RGD:70933
See related
Ensembl:ENSRNOG00000005947 AllianceGenome:RGD:70933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pde6g
Summary
Predicted to enable 3',5'-cyclic-GMP phosphodiesterase activity and cGMP binding activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in photoreceptor outer segment membrane. Orthologous to human PDE6H (phosphodiesterase 6H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 84.8), Thymus (RPKM 18.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
4q43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171588896..171604142)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169857793..169872969)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (170947723..170963046)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor beta Neighboring gene uncharacterized LOC134486856 Neighboring gene uncharacterized LOC134486651 Neighboring gene small nucleolar RNA SNORA62/SNORA6 family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development. Wang H, et al. Biochem Soc Trans, 2004 Nov. PMID 15494017
  2. The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts. Tate RJ, et al. Genomics, 2002 Apr. PMID 11944991
  3. Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5. Cote RH. Int J Impot Res, 2004 Jun. PMID 15224133
  4. The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. Wan KF, et al. J Biol Chem, 2001 Oct 12. PMID 11502744
  5. A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins. Morin F, et al. Mol Vis, 2003 Sep 18. PMID 14502124

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development [review]
    Title: PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in photoreceptor outer segment membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Names
GMP-PDE gamma
phosphodiesterase 6G, cGMP-specific, rod, gamma
phosphodiesterase 6H, cGMP-specific, cone, gamma
NP_446140.1
XP_006237620.1
XP_063141462.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053688.2 → NP_446140.1  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

    See identical proteins and their annotated locations for NP_446140.1

    Status: VALIDATED

    Source sequence(s)
    AF169390, AI070066
    UniProtKB/Swiss-Prot
    P61250
    UniProtKB/TrEMBL
    A6IMK0
    Related
    ENSRNOP00000007905.2, ENSRNOT00000007905.4
    Conserved Domains (1) summary
    pfam04868
    Location:2 → 83
    PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    171588896..171604142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237558.5 → XP_006237620.1  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_006237620.1

    UniProtKB/Swiss-Prot
    P61250
    UniProtKB/TrEMBL
    A6IMK0
    Conserved Domains (1) summary
    pfam04868
    Location:2 → 83
    PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit

  2. XM_063285392.1 → XP_063141462.1  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1

    UniProtKB/Swiss-Prot
    P61250
    UniProtKB/TrEMBL
    A6IMK0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61250.1 GenPept UniProtKB/Swiss-Prot:P61250

Gene LinkOut

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