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Slc28a3 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 [ Mus musculus (house mouse) ]

Gene ID: 114304, updated on 2-Nov-2024

Summary

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Official Symbol
Slc28a3provided by MGI
Official Full Name
solute carrier family 28 (sodium-coupled nucleoside transporter), member 3provided by MGI
Primary source
MGI:MGI:2137361
See related
Ensembl:ENSMUSG00000021553 AllianceGenome:MGI:2137361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cnt3
Summary
Enables purine-specific nucleoside:sodium symporter activity and pyrimidine- and adenosine-specific:sodium symporter activity. Acts upstream of or within purine nucleoside transmembrane transport and pyrimidine nucleoside transport. Located in brush border membrane. Is expressed in pancreas. Orthologous to human SLC28A3 (solute carrier family 28 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in genital fat pad adult (RPKM 5.2), large intestine adult (RPKM 5.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Slc28a3 in Genome Data Viewer
Location:
13 B1; 13 31.07 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58701121..58758691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58553307..58610877, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57600 Neighboring gene STARR-positive B cell enhancer ABC_E1464 Neighboring gene predicted gene, 38494 Neighboring gene chaperonin containing Tcp1, subunit 7 (eta) pseudogene Neighboring gene predicted gene, 34058 Neighboring gene RIKEN cDNA 4930455J16 gene Neighboring gene STARR-seq mESC enhancer starr_34692 Neighboring gene ribosomal protein L13, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Ritzel MW, et al. J Biol Chem, 2001 Jan 26. PMID 11032837
  2. Role of the transporter regulator protein (RS1) in the modulation of concentrative nucleoside transporters (CNTs) in epithelia. Errasti-Murugarren E, et al. Mol Pharmacol, 2012 Jul. PMID 22492015
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables purine-specific nucleoside:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine-specific nucleoside:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyrimidine- and adenosine-specific:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrimidine- and adenosine-specific:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nucleoside transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleobase transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleoside transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within purine nucleoside transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine nucleobase transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleoside transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pyrimidine nucleoside transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine-containing compound transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in retina homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in uridine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in uridine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
solute carrier family 28 member 3
Names
CNT 3
concentrative Na(+)-nucleoside cotransporter 3
concentrative Na+-nucleoside cotransporter
mCNT3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022317.3 → NP_071712.3  solute carrier family 28 member 3

    See identical proteins and their annotated locations for NP_071712.3

    Status: VALIDATED

    Source sequence(s)
    AC154222, AF305211, BY736278
    Consensus CDS
    CCDS26572.1
    UniProtKB/Swiss-Prot
    Q3UM72, Q8BWE2, Q91VD7, Q9ERH8
    Related
    ENSMUSP00000022036.8, ENSMUST00000022036.14
    Conserved Domains (4) summary
    TIGR00804
    Location:216 → 627
    nupC; nucleoside transporter
    pfam01773
    Location:221 → 290
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:403 → 627
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:302 → 398
    Gate; Nucleoside recognition

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    58701121..58758691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERH8.1 GenPept UniProtKB/Swiss-Prot:Q9ERH8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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