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Acr acrosin prepropeptide [ Mus musculus (house mouse) ]

Gene ID: 11434, updated on 28-Oct-2024

Summary

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Official Symbol
Acrprovided by MGI
Official Full Name
acrosin prepropeptideprovided by MGI
Primary source
MGI:MGI:87884
See related
Ensembl:ENSMUSG00000022622 AllianceGenome:MGI:87884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables peptidase activity. Involved in single fertilization. Acts upstream of or within binding activity of sperm to zona pellucida and penetration of zona pellucida. Located in acrosomal vesicle. Is expressed in testis. Human ortholog(s) of this gene implicated in spermatogenic failure 87. Orthologous to human ACR (acrosin). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 49.5) and CNS E18 (RPKM 1.3) See more
Orthologs
human all
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Genomic context

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See Acr in Genome Data Viewer
Location:
15 E3; 15 44.96 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89452549..89458790)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89568326..89578853)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 3 Neighboring gene predicted gene 15609 Neighboring gene STARR-seq mESC enhancer starr_39468 Neighboring gene predicted gene, 36221 Neighboring gene RAB, member RAS oncogene family-like 2 Neighboring gene STARR-seq mESC enhancer starr_39470 Neighboring gene NMD3 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cDNA cloning and functional analysis of ascidian sperm proacrosin. Kodama E, et al. J Biol Chem, 2001 Jul 6. PMID 11313341
  2. Acrosin biosynthesis in meiotic and postmeiotic spermatogenic cells. Kashiwabara S, et al. Biochem Biophys Res Commun, 1990 Nov 30. PMID 1701633
  3. Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Karlin A, et al. Neuron, 1995 Dec. PMID 8845149
  4. Structure and organization of the mouse acrosin gene. Watanabe K, et al. J Biochem, 1991 Jun. PMID 1939002
  5. Mouse preproacrosin: cDNA sequence, primary structure and postmeiotic expression in spermatogenesis. Klemm U, et al. Differentiation, 1990 Feb. PMID 2111255

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SERPINA3K is involved in the Clock gene-mediated male fertility by regulating acrosin activity and provide the first evidence that SERPINA3K could be regulated by Clock gene via retinoic acid-related orphan receptor response elements.
    Title: The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K.
  2. ACR or PRSS21 or both may function cooperatively with SPAM1 in sperm/cumulus penetration
    Title: Functional characterization of double-knockout mouse sperm lacking SPAM1 and ACR or SPAM1 and PRSS21 in fertilization.
  3. These data demonstrate that the trypsinlike protease activity of ACR and PRSS21 is essential for the process of sperm penetration through the cumulus matrix and zona pellucida in vitro
    Title: Mice lacking two sperm serine proteases, ACR and PRSS21, are subfertile, but the mutant sperm are infertile in vitro.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124043

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-mannose binding ISO
Inferred from Sequence Orthology
more info
  
enables D-mannose binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables amidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables fucose binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables serine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in acrosome matrix dispersal IEA
Inferred from Electronic Annotation
more info
  
involved_in acrosome matrix dispersal ISO
Inferred from Sequence Orthology
more info
  
involved_in acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acrosome reaction ISO
Inferred from Sequence Orthology
more info
  
involved_in acrosome reaction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in acrosome reaction TAS
Traceable Author Statement
more info
 PubMed 
involved_in activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within binding of sperm to zona pellucida IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within penetration of zona pellucida IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within penetration of zona pellucida IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in penetration of zona pellucida ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to steroid hormone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to steroid hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi-associated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in acrosomal matrix TAS
Traceable Author Statement
more info
 PubMed 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acrosin
Names
preproacrosin
NP_001191978.1
NP_001264174.1
NP_001264175.1
NP_001264176.1
NP_001398097.1
NP_001398098.1
NP_038483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205049.2 → NP_001191978.1  acrosin isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122401
    UniProtKB/TrEMBL
    Q3ZB04
    Conserved Domains (2) summary
    smart00020
    Location:42 → 238
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:43 → 238
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001277245.2 → NP_001264174.1  acrosin isoform 3

    See identical proteins and their annotated locations for NP_001264174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' end, which results in the use of a downstream AUG translation initiation site, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1. Variants 3, 4 and 7 encode the same isoform (3).
    Source sequence(s)
    AC122401
    UniProtKB/TrEMBL
    Q3ZB05, Q3ZB06
    Conserved Domains (1) summary
    smart00020
    Location:1 → 230
    Tryp_SPc; Trypsin-like serine protease

  3. NM_001277246.2 → NP_001264175.1  acrosin isoform 3

    See identical proteins and their annotated locations for NP_001264175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' end, which results in the use of a downstream AUG translation initiation site, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1. Variants 3, 4 and 7 encode the same isoform (3).
    Source sequence(s)
    AC122401
    UniProtKB/TrEMBL
    Q3ZB05, Q3ZB06
    Conserved Domains (1) summary
    smart00020
    Location:1 → 230
    Tryp_SPc; Trypsin-like serine protease

  4. NM_001277247.2 → NP_001264176.1  acrosin isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC122401
    UniProtKB/TrEMBL
    Q3ZB06
    Conserved Domains (2) summary
    smart00020
    Location:27 → 244
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:26 → 247
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. NM_001411168.1 → NP_001398097.1  acrosin isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 5, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122401
    Related
    ENSMUSP00000155369.2, ENSMUST00000230978.2

  6. NM_001411169.1 → NP_001398098.1  acrosin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' end, which results in the use of a downstream AUG translation initiation site, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1. Variants 3, 4 and 7 encode the same isoform (3).
    Source sequence(s)
    AC122401
    UniProtKB/TrEMBL
    Q3ZB05

  7. NM_013455.4 → NP_038483.1  acrosin isoform 1 precursor

    See identical proteins and their annotated locations for NP_038483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC122401
    Consensus CDS
    CCDS27755.1
    UniProtKB/Swiss-Prot
    P23578
    UniProtKB/TrEMBL
    Q3ZB06
    Related
    ENSMUSP00000023295.3, ENSMUST00000023295.3
    Conserved Domains (2) summary
    smart00020
    Location:42 → 286
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:43 → 289
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89452549..89458790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001277248.1: Suppressed sequence

    Description
    NM_001277248.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23578.1 GenPept UniProtKB/Swiss-Prot:P23578

Gene LinkOut

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