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Chrng cholinergic receptor, nicotinic, gamma polypeptide [ Mus musculus (house mouse) ]

Gene ID: 11449, updated on 2-Nov-2024

Summary

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Official Symbol
Chrngprovided by MGI
Official Full Name
cholinergic receptor, nicotinic, gamma polypeptideprovided by MGI
Primary source
MGI:MGI:87895
See related
Ensembl:ENSMUSG00000026253 AllianceGenome:MGI:87895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acrg; Achr-3
Summary
Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within regulation of membrane potential. Located in postsynaptic membrane. Part of acetylcholine-gated channel complex. Is expressed in several structures, including diaphragm; face; limb bud; rib cartilage condensation; and skeletal musculature. Human ortholog(s) of this gene implicated in contractures, pterygia, and spondylocarpotarsal fusion syndrome. Orthologous to human CHRNG (cholinergic receptor nicotinic gamma subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 16.1), CNS E11.5 (RPKM 1.2) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Chrng in Genome Data Viewer
Location:
1 C5; 1 44.07 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87133533..87139365)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87205811..87211835)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine protease 56 Neighboring gene cholinergic receptor, nicotinic, delta polypeptide Neighboring gene eukaryotic translation initiation factor 4E member 2 Neighboring gene STARR-seq mESC enhancer starr_01608 Neighboring gene STARR-seq mESC enhancer starr_01609 Neighboring gene predicted gene, 53571 Neighboring gene predicted gene, 26187

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Amino- and carboxyl-terminal domains specify the identity of the delta subunit in assembly of the mouse muscle nicotinic acetylcholine receptor. Yu XM, et al. Mol Pharmacol, 1994 Nov. PMID 7969087
  2. Functional Changes Of Fetal Muscle Acetylcholine Receptor During Mouse Development. Grassi F, et al. News Physiol Sci, 1998 Oct. PMID 11390797
  3. AChR channel conversion and AChR-adjusted neuronal survival during embryonic development. Yampolsky P, et al. Mol Cell Neurosci, 2008 Mar. PMID 18226545
  4. Transcriptional regulation of nicotinic acetylcholine receptor genes: identification of control elements of a gamma-subunit gene. Gardner PD, et al. Brain Res, 1987 Dec. PMID 3480767
  5. Isolation and sequence of cDNA clones coding for the precursor to the gamma subunit of mouse muscle nicotinic acetylcholine receptor. Boulter J, et al. J Neurosci Res, 1986. PMID 3755765

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The presence of two new transcript variants (T1 and T2) of chrng expressed in mouse postnatal day 3 and adult skeletal muscles, is reported.
    Title: Alternatively spliced variants of gamma-subunit of muscle-type acetylcholine receptor in fetal and adult skeletal muscle of mouse.
  2. hair cells transiently express alpha1gamma-containing nAChRs in addition to alpha9alpha10, and that these may have a role during development of the inner ear innervation
    Title: The α1 subunit of nicotinic acetylcholine receptors in the inner ear: transcriptional regulation by ATOH1 and co-expression with the γ subunit in hair cells.
  3. Results demonstrate that the gamma-subunit is required for the formation of pre-patterned AChR clusters, which in turn play an essential role in determining the subsequent pattern of neuromuscular synaptogenesis.
    Title: Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning.
  4. Results suggest a requirement for gamma-acetylcholine receptors in mediating synaptically-induced action potential activity critical for neuromuscular development.
    Title: Spontaneous muscle action potentials fail to develop without fetal-type acetylcholine receptors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables ligand-gated monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acetylcholine receptor subunit gamma
Names
nicotinic acetylcholine receptor gamma subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411849.1 → NP_001398778.1  acetylcholine receptor subunit gamma isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102611

  2. NM_009604.4 → NP_033734.3  acetylcholine receptor subunit gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_033734.3

    Status: VALIDATED

    Source sequence(s)
    AC102611
    Consensus CDS
    CCDS35651.1
    UniProtKB/Swiss-Prot
    P04760
    UniProtKB/TrEMBL
    F8VQK4
    Related
    ENSMUSP00000027470.8, ENSMUST00000027470.14
    Conserved Domains (3) summary
    TIGR00860
    Location:23 → 497
    LIC; Cation transporter family protein
    pfam02931
    Location:26 → 241
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:248 → 494
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    87133533..87139365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529078.3 → XP_006529141.1  acetylcholine receptor subunit gamma isoform X1

    UniProtKB/Swiss-Prot
    P04760
    Conserved Domains (2) summary
    cd19029
    Location:71 → 263
    LGIC_ECD_nAChR_G; extracellular domain of nicotinic acetylcholine receptor subunit gamma (CHRNG)
    pfam02932
    Location:270 → 515
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04760.1 GenPept UniProtKB/Swiss-Prot:P04760

Gene LinkOut

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