U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114513, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Rasgrf2provided by RGD
Official Full Name
RAS protein-specific guanine nucleotide-releasing factor 2provided by RGD
Primary source
RGD:69413
See related
EnsemblRapid:ENSRNOG00000056151 AllianceGenome:RGD:69413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in response to endoplasmic reticulum stress. Predicted to act upstream of or within long-term synaptic potentiation and regulation of NMDA receptor activity. Predicted to be located in endoplasmic reticulum. Orthologous to human RASGRF2 (Ras protein specific guanine nucleotide releasing factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 85.6), Brain (RPKM 75.4) and 6 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2q12
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (24848699..25096773, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (23113613..23361537, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (21460041..21698937, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100551 Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene mutS homolog 3 Neighboring gene dihydrofolate reductase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein expression in the rat striatum in vivo. Zhang GC, et al. Neurosci Lett, 2007 Nov 5. PMID 17931779
  2. Analysis of candidate genes included in the mammary cancer susceptibility 1 (Mcs1) region. Laes JF, et al. Mamm Genome, 2001 Mar. PMID 11252168
  3. The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Fan WT, et al. Curr Biol, 1998 Jul 30-Aug 13. PMID 9707409
  4. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Arozarena I, et al. Mol Cell Biol, 2004 Feb. PMID 14749369, Free PMC Article
  5. Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. Tian X, et al. EMBO J, 2004 Apr 7. PMID 15029245, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data identify the Ras activator, Ras-GRF1, although not Ras-GRF2, as a susceptible target to cocaine stimulation in striatal neurons
    Title: Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein expression in the rat striatum in vivo.
  2. RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex
    Title: Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ras-specific guanine nucleotide-releasing factor 2
Names
guanine nucleotide-releasing factor 2
ras guanine nucleotide exchange factor 2
ras-GRF2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053721.3 → NP_446173.2  ras-specific guanine nucleotide-releasing factor 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q99JE4
    UniProtKB/TrEMBL
    A0A8I6AL55
    Related
    ENSRNOP00000069761.3, ENSRNOT00000080165.3
    Conserved Domains (5) summary
    smart00147
    Location:950 → 1186
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00233
    Location:480 → 588
    PH; Pleckstrin homology domain
    smart00325
    Location:247 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19 → 158
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    cl02520
    Location:852 → 924
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    24848699..25096773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101563.2 → XP_038957491.1  ras-specific guanine nucleotide-releasing factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q99JE4
    Conserved Domains (6) summary
    smart00147
    Location:935 → 1171
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00325
    Location:247 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19 → 158
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:480 → 587
    PH; PH domain
    pfam00618
    Location:623 → 671
    RasGEF_N; RasGEF N-terminal motif
    cl02520
    Location:837 → 909
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  2. XM_063281151.1 → XP_063137221.1  ras-specific guanine nucleotide-releasing factor 2 isoform X2

    UniProtKB/Swiss-Prot
    Q99JE4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JE4.1 GenPept UniProtKB/Swiss-Prot:Q99JE4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous