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Lancl1 LanC like glutathione S-transferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114515, updated on 2-Nov-2024

Summary

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Official Symbol
Lancl1provided by RGD
Official Full Name
LanC like glutathione S-transferase 1provided by RGD
Primary source
RGD:69416
See related
EnsemblRapid:ENSRNOG00000013557 AllianceGenome:RGD:69416
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p40; GPR69A
Summary
Predicted to enable several functions, including SH3 domain binding activity; glutathione binding activity; and glutathione transferase activity. Predicted to be involved in cellular detoxification. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human LANCL1 (LanC like glutathione S-transferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 777.3), Brain (RPKM 399.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lancl1 in Genome Data Viewer
Location:
9q32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (75968284..75998397, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (68515052..68548646, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (74018192..74048098, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene pumilio RNA-binding family member 3, pseudogene 2 Neighboring gene large ribosomal subunit protein eL32-like Neighboring gene uncharacterized LOC134480382 Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis. Nielsen JE, et al. Eur J Histochem, 2003. PMID 14514412
  2. Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival. Huang C, et al. Dev Cell, 2014 Aug 25. PMID 25158856, Free PMC Article
  3. Characterization of p40/GPR69A as a peripheral membrane protein related to the lantibiotic synthetase component C. Bauer H, et al. Biochem Biophys Res Commun, 2000 Aug 18. PMID 10944443
  4. Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Zhang W, et al. Genes Dev, 2009 Jun 15. PMID 19528316, Free PMC Article
  5. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense. Zhong WX, et al. J Biol Chem, 2012 Oct 5. PMID 22891245, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense.
    Title: Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.
  2. expression of LanCL1 mutants defective in Eps8 interaction inhibits nerve growth factor (NGF)-induced neurite outgrowth
    Title: Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione.
  3. LanC-like protein 1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse.
    Title: Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC93999

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione binding IEA
Inferred from Electronic Annotation
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
NOT involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular detoxification ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular detoxification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptide modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
NOT located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione S-transferase LANCL1
Names
40 kDa erythrocyte membrane protein
LanC lantibiotic synthetase component C-like 1
LanC like 1
LanC-like 1(bacterial)
lanC (bacterial lantibiotic synthetase component C)-like 1
lanC-like protein 1
NP_446175.1
XP_038938832.1
XP_038938833.1
XP_063122604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053723.1 → NP_446175.1  glutathione S-transferase LANCL1

    See identical proteins and their annotated locations for NP_446175.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ131111
    UniProtKB/Swiss-Prot
    Q9ER29, Q9QX69
    UniProtKB/TrEMBL
    A0A8I6A0Q6, A6KFE1
    Related
    ENSRNOP00000084242.2, ENSRNOT00000108238.2
    Conserved Domains (2) summary
    cd04794
    Location:62 → 395
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:1 → 94
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    75968284..75998397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266534.1 → XP_063122604.1  glutathione S-transferase LANCL1 isoform X1

    UniProtKB/Swiss-Prot
    Q9ER29, Q9QX69
    UniProtKB/TrEMBL
    A6KFE1
    Related
    ENSRNOP00000018293.5, ENSRNOT00000018293.7

  2. XM_039082904.2 → XP_038938832.1  glutathione S-transferase LANCL1 isoform X1

    UniProtKB/Swiss-Prot
    Q9ER29, Q9QX69
    UniProtKB/TrEMBL
    A0A8I6A0Q6, A6KFE1
    Conserved Domains (2) summary
    cd04794
    Location:62 → 395
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:1 → 94
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

  3. XM_039082905.2 → XP_038938833.1  glutathione S-transferase LANCL1 isoform X1

    UniProtKB/Swiss-Prot
    Q9ER29, Q9QX69
    UniProtKB/TrEMBL
    A0A8I6A0Q6, A6KFE1
    Conserved Domains (2) summary
    cd04794
    Location:62 → 395
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:1 → 94
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QX69.2 GenPept UniProtKB/Swiss-Prot:Q9QX69

Gene LinkOut

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