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Cntn5 contactin 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114589, updated on 10-Jul-2024

Summary

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Official Symbol
Cntn5provided by RGD
Official Full Name
contactin 5provided by RGD
Primary source
RGD:621302
See related
EnsemblRapid:ENSRNOG00000007038 AllianceGenome:RGD:621302
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nb-2
Summary
Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in cell-cell adhesion and nervous system development. Predicted to act upstream of or within sensory perception of sound. Predicted to be active in GABA-ergic synapse; axon; and plasma membrane. Predicted to be anchored component of presynaptic membrane. Orthologous to human CNTN5 (contactin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 39.3) See more
Orthologs
human mouse all
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Genomic context

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See Cntn5 in Genome Data Viewer
Location:
8q11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (15017424..16249418, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (6735715..7967727, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (7812371..9033962, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 60 Neighboring gene mitochondrial pyruvate carrier 1-like, pseudogene 2 Neighboring gene TATA element modulatory factor-like Neighboring gene uncharacterized LOC102548563 Neighboring gene prohibitin 1, pseudogene 18 Neighboring gene uncharacterized LOC134479992 Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene Serine/threonine-protein kinase Sgk1, pseudogene 1 Neighboring gene uncharacterized LOC120094309 Neighboring gene nucleophosmin 1, pseudogene 17 Neighboring gene heterogeneous nuclear ribonucleoprotein L, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Preferential localization of neural cell recognition molecule NB-2 in developing glutamatergic neurons in the rat auditory brainstem. Toyoshima M, et al. J Comp Neurol, 2009 Apr 1. PMID 19177518
  2. Neural recognition molecule NB-2 of the contactin/F3 subgroup in rat: Specificity in neurite outgrowth-promoting activity and restricted expression in the brain regions. Ogawa J, et al. J Neurosci Res, 2001 Jul 15. PMID 11438979
  3. Aberrant responses to acoustic stimuli in mice deficient for neural recognition molecule NB-2. Li H, et al. Eur J Neurosci, 2003 Mar. PMID 12653969
  4. Novel neural adhesion molecules in the Contactin/F3 subgroup of the immunoglobulin superfamily: isolation and characterization of cDNAs from rat brain. Ogawa J, et al. Neurosci Lett, 1996 Nov 8. PMID 8945756
  5. A cis-complex of NB-2/contactin-5 with amyloid precursor-like protein 1 is localized on the presynaptic membrane. Shimoda Y, et al. Neurosci Lett, 2012 Feb 29. PMID 22285261

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings suggest that NB-2 plays a key role in maturation of glutamatergic synapses in the brainstem during the final stages of auditory development
    Title: Preferential localization of neural cell recognition molecule NB-2 in developing glutamatergic neurons in the rat auditory brainstem.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in presynapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
contactin-5
Names
neural recognition molecule NB-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053746.1 → NP_446198.1  contactin-5 precursor

    See identical proteins and their annotated locations for NP_446198.1

    Status: PROVISIONAL

    Source sequence(s)
    D87212
    UniProtKB/Swiss-Prot
    P97527
    UniProtKB/TrEMBL
    A6JN62, F1M173
    Related
    ENSRNOP00000009418.8, ENSRNOT00000009418.9
    Conserved Domains (5) summary
    cd04969
    Location:496 → 568
    Ig5_Contactin_like; Fifth Ig domain of contactin
    smart00410
    Location:205 → 278
    IG_like; Immunoglobulin like
    cd00063
    Location:671 → 768
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:480 → 568
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:98 → 191
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    15017424..16249418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595409.2 → XP_017450898.1  contactin-5 isoform X1

    UniProtKB/Swiss-Prot
    P97527
    UniProtKB/TrEMBL
    A6JN62, F1M173

  2. XM_017595411.3 → XP_017450900.1  contactin-5 isoform X2

    UniProtKB/TrEMBL
    F1M173
    Related
    ENSRNOP00000109036.1, ENSRNOT00000162546.1

  3. XM_017595408.3 → XP_017450897.1  contactin-5 isoform X1

    UniProtKB/Swiss-Prot
    P97527
    UniProtKB/TrEMBL
    A6JN62, F1M173

  4. XM_039080701.2 → XP_038936629.1  contactin-5 isoform X3

    Conserved Domains (3) summary
    cd00096
    Location:100 → 104
    Ig; Ig strand A [structural motif]
    cd04969
    Location:480 → 568
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:98 → 193
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97527.1 GenPept UniProtKB/Swiss-Prot:P97527

Gene LinkOut

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