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Ptpre protein tyrosine phosphatase, receptor type, E [ Rattus norvegicus (Norway rat) ]

Gene ID: 114767, updated on 2-Nov-2024

Summary

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Official Symbol
Ptpreprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Eprovided by RGD
Primary source
RGD:620771
See related
EnsemblRapid:ENSRNOG00000015717 AllianceGenome:RGD:620771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PTPepsilon
Summary
Predicted to enable identical protein binding activity and protein tyrosine phosphatase activity. Involved in negative regulation of insulin receptor signaling pathway. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Orthologous to human PTPRE (protein tyrosine phosphatase receptor type E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 59.8), Spleen (RPKM 52.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptpre in Genome Data Viewer
Location:
1q41
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (199774195..199924646)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (190344331..190494815)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (207820719..207987123)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485187 Neighboring gene clarin 3 Neighboring gene uncharacterized LOC102551963 Neighboring gene marker of proliferation Ki-67 Neighboring gene uncharacterized LOC134484914

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distinct promoters control transmembrane and cytosolic protein tyrosine phosphatase epsilon expression during macrophage differentiation. Tanuma N, et al. Eur J Biochem, 1999 Jan. PMID 9914474
  2. Molecular cloning of a novel cytoplasmic protein tyrosine phosphatase PTP epsilon. Nakamura K, et al. Biochem Biophys Res Commun, 1996 Jan 26. PMID 8579581
  3. Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells. Shimizu H, et al. Am J Physiol Cell Physiol, 2010 Nov. PMID 20686073
  4. Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis. Kappert K, et al. Arterioscler Thromb Vasc Biol, 2006 Dec. PMID 16990553
  5. Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses. Akimoto M, et al. Scand J Immunol, 2009 May. PMID 19508371

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that PTPepsilonM negatively regulates PDGFRbeta-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis, and PTPepsilonM may be involved in diabetes-accelerated atherosclerosis.
    Title: Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells.
  2. Antioxidants inhibited neointima formation and reduced PDGF receptor phosphorylation in the neointima and also increased PTP activity.
    Title: Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis.
  3. Data suggest that protein tyrosine phosphatase epsilonM negatively regulates the development of atherosclerosis by activating c-Src.
    Title: Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor protein tyrosine phosphatase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase epsilon
Names
R-PTP-epsilon
protein tyrosine phosphatase epsilon
protein tyrosine phosphatase epsilon-like 1
protein tyrosine phosphatase epsilon-like 2
protein tyrosine phosphatase, receptor type, epsilon
NP_446219.1
XP_006230511.1
XP_006230512.3
XP_038964618.1
XP_038964717.1
XP_063119170.1
XP_063119306.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053767.3 → NP_446219.1  receptor-type tyrosine-protein phosphatase epsilon precursor

    See identical proteins and their annotated locations for NP_446219.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    B2GV87, Q63476, Q63477
    UniProtKB/TrEMBL
    A0A8L2QB53
    Related
    ENSRNOP00000080854.2, ENSRNOT00000098076.2
    Conserved Domains (2) summary
    cd14620
    Location:164 → 392
    R-PTPc-E-1; catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1
    cl28904
    Location:479 → 688
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    199774195..199924646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108789.2 → XP_038964717.1  receptor-type tyrosine-protein phosphatase epsilon isoform X4

    Conserved Domains (1) summary
    cl28904
    Location:184 → 354
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_039108690.2 → XP_038964618.1  receptor-type tyrosine-protein phosphatase epsilon isoform X1

    UniProtKB/TrEMBL
    A0A8I6AUL6, A0A8L2QB53
    Related
    ENSRNOP00000021359.8, ENSRNOT00000021359.10
    Conserved Domains (2) summary
    cd14620
    Location:184 → 412
    R-PTPc-E-1; catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1
    cl28904
    Location:499 → 708
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_006230449.5 → XP_006230511.1  receptor-type tyrosine-protein phosphatase epsilon isoform X2

    See identical proteins and their annotated locations for XP_006230511.1

    UniProtKB/Swiss-Prot
    B2GV87, Q63476, Q63477
    UniProtKB/TrEMBL
    A0A8L2QB53
    Conserved Domains (2) summary
    cd14620
    Location:164 → 392
    R-PTPc-E-1; catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1
    cl28904
    Location:479 → 688
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_063263100.1 → XP_063119170.1  receptor-type tyrosine-protein phosphatase epsilon isoform X2

    UniProtKB/Swiss-Prot
    B2GV87, Q63476, Q63477

  5. XM_006230450.5 → XP_006230512.3  receptor-type tyrosine-protein phosphatase epsilon isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZR03
    Related
    ENSRNOP00000078012.1, ENSRNOT00000110825.2

  6. XM_063263236.1 → XP_063119306.1  receptor-type tyrosine-protein phosphatase epsilon isoform X5

RNA

  1. XR_005503825.2 RNA Sequence

  2. XR_010052952.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2GV87.1 GenPept UniProtKB/Swiss-Prot:B2GV87

Gene LinkOut

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