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RNF157 ring finger protein 157 [ Homo sapiens (human) ]

Gene ID: 114804, updated on 5-Mar-2024

Summary

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Official Symbol
RNF157provided by HGNC
Official Full Name
ring finger protein 157provided by HGNC
Primary source
HGNC:HGNC:29402
See related
Ensembl:ENSG00000141576 AllianceGenome:HGNC:29402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of dendrite extension; and protein autoubiquitination. Predicted to be located in cell body. Predicted to be active in early endosome; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 16.0), testis (RPKM 13.4) and 11 other tissues See more
Orthologs
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Genomic context

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Location:
17q25.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76142474..76240493, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77039017..77137048, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74138555..74236574, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74127821-74128482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74128483-74129142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133109-74133770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133771-74134430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74135093-74135752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9005 Neighboring gene RNF157 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74140914-74141462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74141463-74142010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74143158-74143658 Neighboring gene forkhead box J1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:74162894-74164093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74186853-74187352 Neighboring gene ATP synthase membrane subunit g pseudogene 6 Neighboring gene activating transcription factor 4 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74235542-74236214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9007 Neighboring gene uncharacterized LOC105371896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12794 Neighboring gene Sharpr-MPRA regulatory region 14042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12800 Neighboring gene UBA like domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts. Qi T, et al. Invest Ophthalmol Vis Sci, 2022 Apr 1. PMID 35435923, Free PMC Article
  2. Exosomal RNF157 mRNA from prostate cancer cells contributes to M2 macrophage polarization through destabilizing HDAC1. Guan H, et al. Front Oncol, 2022. PMID 36263220, Free PMC Article
  3. Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle. Dogan T, et al. J Biol Chem, 2017 Sep 1. PMID 28655764, Free PMC Article
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. Nagase T, et al. DNA Res, 2001 Aug 31. PMID 11572484
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. van Wijk SJ, et al. Mol Syst Biol, 2009. PMID 19690564, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that RNF157 plays role as downstream effector of both PI3K signaling and MAPK signaling in melanoma cell line; regulation of RNF157 expression is cell-cycle-dependent in melanoma cell line; both CDH1 and CDK2 are involved in modulation of RNF157 stability during melanoma cell proliferation. (PI3K = phosphatidylinositol 3-kinase; CDH1 = E-cadherin; CDK2 = cyclin-dependent kinase 2)
    Title: Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of dendrite extension ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin ligase RNF157
Names
RING-type E3 ubiquitin transferase RNF157
NP_001317430.1
NP_443148.1
XP_011522575.1
XP_016879609.2
XP_047291242.1
XP_047291243.1
XP_047291244.1
XP_047291245.1
XP_054170911.1
XP_054170912.1
XP_054170913.1
XP_054170914.1
XP_054170915.1
XP_054170916.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330501.2 → NP_001317430.1  E3 ubiquitin ligase RNF157 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA609513, AB067504, AC015801, AK091467, BM310065, BM722923, BQ434552, CX872674
    Consensus CDS
    CCDS82208.1
    UniProtKB/Swiss-Prot
    Q96PX1
    Related
    ENSP00000321837.4, ENST00000319945.10

  2. NM_052916.3 → NP_443148.1  E3 ubiquitin ligase RNF157 isoform 1

    See identical proteins and their annotated locations for NP_443148.1

    Status: VALIDATED

    Source sequence(s)
    AA932192, AB067504, AC015801, AK055949, AK091467, BI857136, BM474134, CX872674
    Consensus CDS
    CCDS32740.1
    UniProtKB/Swiss-Prot
    Q8NB72, Q96N56, Q96PX1
    Related
    ENSP00000269391.4, ENST00000269391.11
    Conserved Domains (1) summary
    pfam13920
    Location:276 → 318
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    76142474..76240493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435287.1 → XP_047291243.1  E3 ubiquitin ligase RNF157 isoform X2

  2. XM_047435286.1 → XP_047291242.1  E3 ubiquitin ligase RNF157 isoform X1

    UniProtKB/TrEMBL
    A0A3B3ISM3
    Related
    ENSP00000497353.1, ENST00000647930.1

  3. XM_047435288.1 → XP_047291244.1  E3 ubiquitin ligase RNF157 isoform X3

  4. XM_017024120.3 → XP_016879609.2  E3 ubiquitin ligase RNF157 isoform X4

  5. XM_011524273.4 → XP_011522575.1  E3 ubiquitin ligase RNF157 isoform X6

    Conserved Domains (1) summary
    pfam13920
    Location:276 → 318
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  6. XM_047435289.1 → XP_047291245.1  E3 ubiquitin ligase RNF157 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    77039017..77137048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314937.1 → XP_054170912.1  E3 ubiquitin ligase RNF157 isoform X2

  2. XM_054314936.1 → XP_054170911.1  E3 ubiquitin ligase RNF157 isoform X1

  3. XM_054314938.1 → XP_054170913.1  E3 ubiquitin ligase RNF157 isoform X3

  4. XM_054314939.1 → XP_054170914.1  E3 ubiquitin ligase RNF157 isoform X4

  5. XM_054314941.1 → XP_054170916.1  E3 ubiquitin ligase RNF157 isoform X6

  6. XM_054314940.1 → XP_054170915.1  E3 ubiquitin ligase RNF157 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PX1.3 GenPept UniProtKB/Swiss-Prot:Q96PX1

Gene LinkOut

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