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LOC114827956 VISTA enhancer mm1691 [ Mus musculus (house mouse) ]

Gene ID: 114827956, updated on 9-Aug-2024

Summary

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Gene symbol
LOC114827956
Gene description
VISTA enhancer mm1691
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr1982
Summary
This locus represents a conserved genomic element that can function as an enhancer. It can activate a Hsp68 promoter coupled to a LacZ reporter gene in embryonic somite, midbrain and limb of transgenic mice. A subregion was also identified as a candidate cis-regulatory module (CRM) in developing mouse thymocytes based on a combination of DNase I hypersensitivity and transcription factor binding. That subregion was validated as an enhancer by high-throughput CapStarr-seq reporter assays showing weak activity in P5424 T cells and NIH3T3 fibroblasts. [provided by RefSeq, Mar 2023]
Orthologs
human all
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Genomic context

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See LOC114827956 in Genome Data Viewer
Location:
17; 17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47831710..47834512)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47520785..47523587)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 3 Neighboring gene expressed sequence AI661453 Neighboring gene STARR-seq mESC enhancer starr_42703 Neighboring gene STARR-positive B cell enhancer ABC_E9168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47641447-47641630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47641910-47642097 Neighboring gene TATA-box binding protein associated factor 8 Neighboring gene STARR-positive B cell enhancer ABC_E5616 Neighboring gene STARR-seq mESC enhancer starr_42710 Neighboring gene STARR-positive B cell enhancer ABC_E10958 Neighboring gene cyclin D3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47668330-47668738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47679075-47679320 Neighboring gene predicted gene, 41590 Neighboring gene STARR-seq mESC enhancer starr_42717 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47732923-47733032 Neighboring gene STARR-positive B cell enhancer ABC_E9169 Neighboring gene bystin-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VISTA Enhancer Browser--a database of tissue-specific human enhancers. Visel A, et al. Nucleic Acids Res, 2007 Jan. PMID 17130149, Free PMC Article
  2. High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq. Vanhille L, et al. Nat Commun, 2015 Apr 15. PMID 25872643

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Other Names

  • CapStarr-seq enhancer MGSCv37_chr17:47658599-47658826
  • regulatory region 1982

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065312.1 

    Range
    101..2903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47831710..47834512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version