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Gsto1 glutathione S-transferase omega 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114846, updated on 18-Sep-2024

Summary

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Official Symbol
Gsto1provided by RGD
Official Full Name
glutathione S-transferase omega 1provided by RGD
Primary source
RGD:70952
See related
EnsemblRapid:ENSRNOG00000071889 AllianceGenome:RGD:70952
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SPG-R
Summary
Enables glutathione dehydrogenase (ascorbate) activity. Involved in L-ascorbic acid biosynthetic process. Located in several cellular components, including cell body; myelin sheath; and nuclear membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human GSTO1 (glutathione S-transferase omega 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 922.5), Adrenal (RPKM 568.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gsto1 in Genome Data Viewer
Location:
1q54
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (256662377..256672515)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (246721089..246731228)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267607437..267617387)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene glutathione S-transferase omega 2 Neighboring gene inositol 1,4,5-trisphosphate receptor interacting protein Neighboring gene uncharacterized LOC120100050 Neighboring gene microRNA 3584

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Toward protein biomarkers for allergy: CD4+ T cell proteomics in allergic and nonallergic subjects sampled in and out of pollen season. Blüggel M, et al. J Proteome Res, 2011 Apr 1. PMID 21410266
  2. Subcellular localization of a glutathione-dependent dehydroascorbate reductase within specific rat brain regions. Fornai F, et al. Neuroscience, 2001. PMID 11311527
  3. GSTO1 regulates insulin biosynthesis in pancreatic β cells. Wang L, et al. Biochem Biophys Res Commun, 2020 Apr 16. PMID 32057363
  4. Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. Zakharyan RA, et al. Chem Res Toxicol, 2001 Aug. PMID 11511179
  5. The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. Dulhunty A, et al. J Biol Chem, 2001 Feb 2. PMID 11035031

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GSTO1 regulates insulin biosynthesis in pancreatic beta cells.
    Title: GSTO1 regulates insulin biosynthesis in pancreatic β cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC94845

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutathione dehydrogenase (ascorbate) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione dehydrogenase (ascorbate) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione dehydrogenase (ascorbate) activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione dehydrogenase (ascorbate) activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methylarsonate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-ascorbic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-ascorbic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-ascorbic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-ascorbic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to arsenic-containing substance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutathione S-transferase omega-1
Names
GSTO 1-1
GSTO-1
MMA(V) reductase
S-(Phenacyl)glutathione reductase
glutathione S-transferase omega 1-1
glutathione-dependent dehydroascorbate reductase
monomethylarsonic acid reductase
NP_001007603.1
XP_038964778.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007602.1 → NP_001007603.1  glutathione S-transferase omega-1

    See identical proteins and their annotated locations for NP_001007603.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079363
    UniProtKB/Swiss-Prot
    Q9Z339
    UniProtKB/TrEMBL
    A6JHR8, B6DYQ5, F7F9Z0, Q6AXR6
    Related
    ENSRNOP00000107772.1, ENSRNOT00000128454.1
    Conserved Domains (3) summary
    cd03184
    Location:108 → 229
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    COG0625
    Location:26 → 214
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03055
    Location:5 → 94
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    256662377..256672515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108850.2 → XP_038964778.1  glutathione S-transferase omega-1 isoform X1

    Conserved Domains (2) summary
    cd03055
    Location:5 → 94
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    cl02776
    Location:108 → 199
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z339.2 GenPept UniProtKB/Swiss-Prot:Q9Z339

Gene LinkOut

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