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SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough [ Homo sapiens (human) ]

Gene ID: 115072896, updated on 2-May-2024

Summary

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Official Symbol
SLCO1B3-SLCO1B7provided by HGNC
Official Full Name
SLCO1B3-SLCO1B7 readthroughprovided by HGNC
Primary source
HGNC:HGNC:54403
See related
Ensembl:ENSG00000257046 AllianceGenome:HGNC:54403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LST-3TM12; OATP1B3-1B7
Summary
This locus represents naturally occurring readthrough transcription between the neighboring SLCO1B3 (solute carrier organic anion transporter family member 1B3) and SLCO1B7 (solute carrier organic anion transporter family member 1B7 (putative)) genes on chromosome 12. The readthrough transcript encodes a protein that shares sequence identity with both the upstream and downstream genes. [provided by RefSeq, Jun 2019]
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Genomic context

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See SLCO1B3-SLCO1B7 in Genome Data Viewer
Location:
12p12.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (20815674..21091222)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (20694298..20969842)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (20968608..21244156)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A Neighboring gene Sharpr-MPRA regulatory region 11298 Neighboring gene ubiquitin like with PHD and ring finger domains 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 13494 Neighboring gene Sharpr-MPRA regulatory region 7088 Neighboring gene solute carrier organic anion transporter family member 1C1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:20915672-20916304 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:20921407-20922031 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:20974670-20975869 Neighboring gene solute carrier organic anion transporter family member 1B3 Neighboring gene putative solute carrier organic anion transporter family member 1B7 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:21226346-21227545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:21335031-21335532 Neighboring gene solute carrier organic anion transporter family member 1B1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21367725-21368322 Neighboring gene uncharacterized LOC124903123 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:21386467-21387666 Neighboring gene uncharacterized LOC124902895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:21402494-21402994

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7. Meyer Zu Schwabedissen HE, et al. Pharmacol Res, 2020 Nov. PMID 32818652
  2. OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe. Malagnino V, et al. Mol Pharmacol, 2019 Aug. PMID 31127008
  3. LST-3TM12 is a member of the OATP1B family and a functional transporter. Malagnino V, et al. Biochem Pharmacol, 2018 Feb. PMID 29248594

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7.
    Title: Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in smooth endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SLCO1B3-SLCO1B7 readthrough transcript protein
Names
liver specific transporter-3 transmembrane 12
organic anion transporting polypeptide 1B3-1B7
solute carrier organic anion transporter family member 1B3-1B7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371097.1 → NP_001358026.1  SLCO1B3-SLCO1B7 readthrough transcript protein

    Status: VALIDATED

    Source sequence(s)
    AC011604, AC087309, AY442326
    UniProtKB/TrEMBL
    A0A0A6YYJ9, Q7Z454
    Related
    ENSP00000441269.1, ENST00000540229.1
    Conserved Domains (1) summary
    cl28910
    Location:28 → 561
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    20815674..21091222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    20694298..20969842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F5H094.1 GenPept UniProtKB/Swiss-Prot:F5H094

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials