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DUS4L-BCAP29 DUS4L-BCAP29 readthrough [ Homo sapiens (human) ]

Gene ID: 115253422, updated on 17-Mar-2024

Summary

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Official Symbol
DUS4L-BCAP29provided by HGNC
Official Full Name
DUS4L-BCAP29 readthroughprovided by HGNC
Primary source
HGNC:HGNC:54422
See related
Ensembl:ENSG00000288558 AllianceGenome:HGNC:54422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring readthrough transcription between the neighboring DUS4L (dihydrouridine synthase 4 like) and BCAP29 (B cell receptor associated protein 29) genes on chromosome 7. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2019]
Orthologs
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Genomic context

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Location:
7q22.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (107563971..107623317)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (108880017..108939457)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (107204416..107263762)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 5 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene MPRA-validated peak6680 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:107148389-107148890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:107148891-107149390 Neighboring gene G protein-coupled receptor 22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18539 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:107204943-107206142 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:107204244-107204454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26493 Neighboring gene uncharacterized LOC124901856 Neighboring gene dihydrouridine synthase 4 like Neighboring gene Sharpr-MPRA regulatory region 6605 Neighboring gene B cell receptor associated protein 29 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26494 Neighboring gene WBP1L pseudogene 2 Neighboring gene BANF1 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recurrent fusion RNA DUS4L-BCAP29 in non-cancer human tissues and cells. Tang Y, et al. Oncotarget, 2017 May 9. PMID 28415823, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

General protein information

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Preferred Names
DUS4L-BCAP29 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371364.2 → NP_001358293.1  DUS4L-BCAP29 protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC002381, AC004839, AC078937
    UniProtKB/TrEMBL
    A0A669KAY5
    Related
    ENSP00000501026.1, ENST00000673757.1
    Conserved Domains (4) summary
    pfam05483
    Location:376 → 518
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd02801
    Location:28 → 237
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam05529
    Location:241 → 369
    Bap31; B-cell receptor-associated protein 31-like
    pfam18035
    Location:425 → 470
    Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

  2. NM_001371365.2 → NP_001358294.1  DUS4L-BCAP29 protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 3 and 4, encodes isoform b
    Source sequence(s)
    AC002381, AC004839, AC078937
    UniProtKB/TrEMBL
    A0A669KB27
    Related
    ENSP00000501195.1, ENST00000673970.1
    Conserved Domains (4) summary
    cd02801
    Location:28 → 237
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam02841
    Location:364 → 470
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam05529
    Location:241 → 369
    Bap31; B-cell receptor-associated protein 31-like
    pfam18035
    Location:425 → 479
    Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

  3. NM_001371366.2 → NP_001358295.1  DUS4L-BCAP29 protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 4, encodes isoform b.
    Source sequence(s)
    AC002381, AC004839, AC078937
    UniProtKB/TrEMBL
    A0A669KB27
    Related
    ENSP00000501094.1, ENST00000673780.1
    Conserved Domains (4) summary
    cd02801
    Location:28 → 237
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam02841
    Location:364 → 470
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam05529
    Location:241 → 369
    Bap31; B-cell receptor-associated protein 31-like
    pfam18035
    Location:425 → 479
    Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

  4. NM_001371367.2 → NP_001358296.1  DUS4L-BCAP29 protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC002381, AC004839, AC078937
    UniProtKB/TrEMBL
    A0A669KB27
    Related
    ENSP00000501003.1, ENST00000673720.1
    Conserved Domains (4) summary
    cd02801
    Location:28 → 237
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam02841
    Location:364 → 470
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam05529
    Location:241 → 369
    Bap31; B-cell receptor-associated protein 31-like
    pfam18035
    Location:425 → 479
    Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

RNA

  1. NR_163939.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC002381, AC004839, AC078937
    Related
    ENST00000673992.1

  2. NR_163940.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC002381, AC004839, AC078937
    Related
    ENST00000674062.1

  3. NR_163941.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC002381, AC004839, AC078937
    Related
    ENST00000674049.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    107563971..107623317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_017852930.1 Reference GRCh38.p14 PATCHES

    Range
    409626..468267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    108880017..108939457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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